DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00575
Abstract: Iron homeostasis is an essential prerequisite for metabolic and neurological functions throughout the healthy human life, with a dynamic interplay between intracellular and systemic iron metabolism. The development of different neurodegenerative diseases is associated with… read more here.
Keywords: aging neurodegeneration; dmt1; dmt1 expression; expression iron ... See more keywords
The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.831116
Abstract: Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health. To this end, two cellular compartments with… read more here.
Keywords: uprer uprmt; health; unfolded protein; neurodegeneration ... See more keywords
Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21072477
Abstract: Still unresolved is the question of how a lifetime accumulation of somatic gene copy number alterations impact organ functionality and aging and age-related pathologies. Such an issue appears particularly relevant in the broadly post-mitotic central… read more here.
Keywords: circular dna; dna; aging neurodegeneration; current knowledge ... See more keywords
Nature can still be the strongest help against aging and neurodegeneration: the sirtuins way
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.360173
Abstract: U nfo r t u n ate l y, a g i n g i s n o t a reve rs i b l e phenomenon and the processes of senescence are unavoidable. However,… read more here.
Keywords: nature still; help aging; neurodegeneration sirtuins; still strongest ... See more keywords