NAD+ in Brain Aging and Neurodegenerative Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.09.001
Abstract: NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging… read more here.
Keywords: nad brain; aging neurodegenerative; neurodegenerative disorders; brain ... See more keywords
Neuroimmune Connections in Aging and Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in immunology"
DOI: 10.1016/j.it.2020.02.002
Abstract: In recent years, the inter-relationship between the innate immune system and the central nervous system (CNS) has moved to the forefront of biomedical research, with the discovery that these two physiological systems modulate each other… read more here.
Keywords: connections aging; system; aging neurodegenerative; neuroimmune connections ... See more keywords
The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1124907
Abstract: The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes. This includes maintenance of cellular homeostasis in… read more here.
Keywords: function; brain; proteasome; nervous system ... See more keywords
The effect of epigenetic aging on neurodegenerative diseases: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2024.1372518
Abstract: Background Aging has always been considered as a risk factor for neurodegenerative diseases, but there are individual differences and its mechanism is not yet clear. Epigenetics may unveil the relationship between aging and neurodegenerative diseases.… read more here.
Keywords: epigenetic aging; risk; mendelian randomization; neurodegenerative diseases ... See more keywords
Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1322419
Abstract: The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in… read more here.
Keywords: implications aging; exploring complexities; metabolism; aging neurodegenerative ... See more keywords
The ROSMAP project: aging and neurodegenerative diseases through omic sciences
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Neuroinformatics"
DOI: 10.3389/fninf.2024.1443865
Abstract: The Religious Order Study and Memory and Aging Project (ROSMAP) is an initiative that integrates two longitudinal cohort studies, which have been collecting clinicopathological and molecular data since the early 1990s. This extensive dataset includes… read more here.
Keywords: project aging; rosmap project; diseases omic; neurodegenerative diseases ... See more keywords
Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00132
Abstract: Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges, resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative disorders, these mechanisms are compromised. In fact, neurons show unique age-related changes… read more here.
Keywords: neuronal cells; aging neurodegenerative; stress; metabolism oxidative ... See more keywords
Glycosylation in aging and neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2024 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2024136
Abstract: Aging, a complex biological process, involves the progressive decline of physiological functions across various systems, leading to increased susceptibility to neurodegenerative diseases. In society, demographic aging imposes significant economic and social burdens due to these… read more here.
Keywords: glycosylation aging; diseases glycosylation; neurodegenerative diseases; aging neurodegenerative ... See more keywords