NAD+ in Brain Aging and Neurodegenerative Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.09.001
Abstract: NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging… read more here.
Keywords: nad brain; aging neurodegenerative; neurodegenerative disorders; brain ... See more keywords
Neuroimmune Connections in Aging and Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in immunology"
DOI: 10.1016/j.it.2020.02.002
Abstract: In recent years, the inter-relationship between the innate immune system and the central nervous system (CNS) has moved to the forefront of biomedical research, with the discovery that these two physiological systems modulate each other… read more here.
Keywords: connections aging; system; aging neurodegenerative; neuroimmune connections ... See more keywords
The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1124907
Abstract: The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes. This includes maintenance of cellular homeostasis in… read more here.
Keywords: function; brain; proteasome; nervous system ... See more keywords
Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00132
Abstract: Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges, resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative disorders, these mechanisms are compromised. In fact, neurons show unique age-related changes… read more here.
Keywords: neuronal cells; aging neurodegenerative; stress; metabolism oxidative ... See more keywords