A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes
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DOI: 10.1002/pmic.201600232
Abstract: Circulating polypeptides and proteins have been implicated in reversing or accelerating aging phenotypes, including growth/differentiation factor 8 (GDF8), GDF11, eotaxin, and oxytocin. These proteoforms, which are defined as the protein products arising from a single… read more here.
Keywords: proteomic assay; plasma; aging phenotypes; targeted proteomic ... See more keywords
DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress
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DOI: 10.1007/s11357-024-01360-4
Abstract: Aging of hematopoietic stem cells (HSCs) is implicated in various aging phenotypes, including immune dysfunction, anemia, and malignancies. The role of HSC proliferation in driving these aging phenotypes, particularly under stress conditions, remains unclear. Therefore,… read more here.
Keywords: methylation; dna methylation; stem; proliferative stress ... See more keywords
Analysis of vascular aging phenotypes in a high cardiovascular risk population
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DOI: 10.1038/s41598-025-04988-0
Abstract: Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a… read more here.
Keywords: vascular aging; risk; population; high cardiovascular ... See more keywords
Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila
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DOI: 10.1101/2022.05.23.493120
Abstract: Transposable elements (TE) are mobile sequences of DNA that can become transcriptionally active as an animal ages. Whether TE activity is simply a byproduct of heterochromatin breakdown or can contribute towards the aging process is… read more here.
Keywords: aging phenotypes; artificially stimulating; mortality; activity ... See more keywords
Proteomic landscape of multidimensional aging phenotypes
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DOI: 10.1186/s13073-025-01558-x
Abstract: Proteomic signatures of aging hold promise for advancing our understanding of aging evaluation and guiding targeted therapy. Despite this potential, the proteomic landscape of multidimensional aging phenotypes remains inadequately characterized. We aimed to identify the… read more here.
Keywords: multidimensional aging; proteomic landscape; landscape multidimensional; aging phenotypes ... See more keywords