Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.09.003
Abstract: The proteostasis network (PN) is a nexus of mechanisms that act in concert to maintain the integrity of the proteome. Efficiency of the PN declines with age, resulting in the accumulation of misfolded proteins, and… read more here.
Keywords: aging proteostasis; crossroads aging; neurodegeneration; assemblies crossroads ... See more keywords
The aging proteostasis decline: From nematode to human
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2021.112474
Abstract: The aging proteostasis decline manifests in a failure of aging cells and organisms to properly respond to proteotoxic challenges. This proteostasis collapse has long been considered a hallmark of aging in nematodes, and has recently… read more here.
Keywords: proteostasis decline; aging proteostasis; proteostasis; senescence ... See more keywords