Oral administration of alcalase potato protein hydrolysate‐APPH attenuates high fat diet‐induced cardiac complications via TGF‐β/GSN axis in aging rats
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22651
Abstract: Consumption of high fat diet (HFD) is associated with increased cardiovascular risk factors among elderly people. Aging and obesity induced‐cardiac remodeling includes hypertrophy and fibrosis. Gelsolin (GSN) induces cardiac hypertrophy and TGF‐β, a key cytokine,… read more here.
Keywords: induced cardiac; tgf gsn; tgf; hypertrophy ... See more keywords
Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D‐galactose induced aging in rats
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22671
Abstract: Cardiac fibrosis is a common pathophysiological process observed during chronic and stress‐induced acceleration of cardiac aging. Fibrosis is a necessary process during wound healing and tissue repair. However, its deposition in organs would proceed to… read more here.
Keywords: fibrosis; cardiac fibrosis; fibrosis associated; galactose induced ... See more keywords
Astragaloside IV prevents memory impairment in D-galactose-induced aging rats via the AGEs/RAGE/ NF-κB axis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2021.05.005
Abstract: BACKGROUND We investigated the effects of astragaloside IV (AS-IV) on memory function in aging rats mimicked by D-galactose administration and explored the potential molecular mechanisms. METHODS Twenty-seven male rats were randomly divided into control group… read more here.
Keywords: ages rage; memory impairment; rage axis; galactose induced ... See more keywords
Ameliorative Effect of Ellagic Acid on Aging in Rats with the Potential Mechanism Relying on the Gut Microbiota and Urolithin A-Producing Ability.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00960
Abstract: Ellagic acid (EA) exhibits potential antiaging activity. Differences in individual ability to produce urolithins may result in large interindividual variability in the health effects of EA. Therefore, the effects and mechanism of EA on d-galactose-induced… read more here.
Keywords: ability; gut microbiota; producing ability; aging rats ... See more keywords
Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Rejuvenation research"
DOI: 10.1089/rej.2017.1919
Abstract: Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior… read more here.
Keywords: baicalein; dysfunction; gal induced; attenuation inflammation ... See more keywords
DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/6521146
Abstract: Oxidative stress and neuroinflammation have been demonstrated to be linked with Alzheimer's disease (AD). In this study, we examined the protective effects of DL0410 in aging rats and explored the underlying mechanism against oxidative damage… read more here.
Keywords: tlr4 myd88; neuroinflammation; aging rats; induced aging ... See more keywords
Numeric and volumetric changes in Leydig cells during aging of rats.
Sign Up to like & getrecommendations! Published in 2017 at "Acta cirurgica brasileira"
DOI: 10.1590/s0102-865020170100000002
Abstract: PURPOSE To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. METHODS Seventy-two Wistar rats were divided into six subgroups… read more here.
Keywords: volume; cells aging; number; aging rats ... See more keywords
TSH-independent release of thyroid hormones through cold exposure in aging rats
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19851
Abstract: Thyroid function decreases and cold exposure response becomes impaired with increasing age. We investigated the age-related changes in thyroid structure and function and cold-induced changes in the thyroid activity of aging rats. Thirty-two male Sprague–Dawley… read more here.
Keywords: changes thyroid; young rats; cold exposure; old rats ... See more keywords
Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in d-galactose-induced aging rats
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s132277
Abstract: Background Recently, the d-galactose (d-gal)-induced mimetic aging rat model has been widely used in studies of age-associated diseases, which have shown that chronic d-gal exposure induces premature aging similar to natural aging in rats. With… read more here.
Keywords: sepsis; inflammatory response; gal induced; model ... See more keywords
Changes of Colon in Rats with Different Ages in Response to Lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230113112803
Abstract: BACKGROUND Lipopolysaccharide (LPS) is an endotoxin that causes inflammation, and the content of LPS increases gradually during the process of aging. Whether the response of the colon to LPS stimulation will increase with age is… read more here.
Keywords: response; aging rats; changes colon; lps stimulation ... See more keywords
Portulaca oleracea polysaccharides reduce serum lipid levels in aging rats by modulating intestinal microbiota and metabolites
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.965653
Abstract: Metabolic diseases characterized by dyslipidemia are common health problems for elderly populations. Dietary fiber intake is inversely associated with the risk of dyslipidemia. This study investigated the effects of Portulaca oleracea polysaccharide (POP) on the… read more here.
Keywords: levels aging; intestinal microbiota; microbiota metabolites; portulaca oleracea ... See more keywords