Aging related cognitive changes associated with Alzheimer's disease in Down syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.571
Abstract: Individuals with Down syndrome (DS) have an extremely high genetic risk for Alzheimer's disease (AD), however, the course of cognitive decline associated with progression to dementia is ill‐defined. Data‐driven methods can estimate long‐term trends from… read more here.
Keywords: alzheimer disease; disease; aging related; related cognitive ... See more keywords
Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501070
Abstract: Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic inflammation. This… read more here.
Keywords: related myocardial; fibrosis; myocardial fibrosis; indole propionic ... See more keywords
PRDM16 Reduces Cellular Senescence by Upregulating GSTM1
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501233
Abstract: Cellular senescence is a hallmark of aging and the accumulation of senescent cells (SnCs) accelerates the aging process, contributing to aging‐related organ disorders. The PRDF1 and RIZ1 homology domain (PRDM) protein exhibits robust transcriptional regulatory… read more here.
Keywords: senescence; cellular senescence; aging related; gstm1 ... See more keywords
Aging‐related prognosis analysis of definitive radiotherapy for very elderly esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1456
Abstract: Because of the exclusion for the patients more than 75 years (very elderly patients) in many clinical trials of esophageal cancer (EC), there is no consensus on prognosis and treatment for this population. We aim… read more here.
Keywords: esophageal cancer; aging related; elderly patients; cancer ... See more keywords
A risk model of 10 aging‐related genes for predicting survival and immune response in triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4674
Abstract: Accumulated studies showed that the clinical significance of aging on the development and malignancy of tumors, while the relationship between aging and the prognosis, immune response in triple‐negative breast cancer (TNBC) has not been well… read more here.
Keywords: risk model; risk; immune response; aging related ... See more keywords
Translatability of mouse muscle-aging for humans: the role of sex
Sign Up to like & getrecommendations! Published in 2024 at "GeroScience"
DOI: 10.1007/s11357-024-01082-7
Abstract: Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have… read more here.
Keywords: muscle aging; muscle; aging related; sex ... See more keywords
SIRT6 Protects Against Myocardial Ischemia–Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-021-10184-y
Abstract: Impaired autophagic flux induces aging-related ischemia vulnerability, which is the hallmark pathology in cardiac aging. Our previous work has confirmed that the accumulation of charged multivesicular body protein 2B (CHMP2B), a subunit of the ESCRT-III… read more here.
Keywords: ischemia; accumulation; chmp2b accumulation; aging related ... See more keywords
β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-024-10569-9
Abstract: The incidence of atrial fibrillation (AF) increases with age; however, the precise mechanisms by which aging elevates AF risk and the effective biomarkers for managing AF in elderly patients remain unclear. We analyzed plasma samples… read more here.
Keywords: citrate synthase; aging related; potential diagnostic; elderly patients ... See more keywords
Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00853-2
Abstract: Neurological disorders such as Alzheimer’s disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying treatments to date and now constitute a dementia crisis that affects 5 million in… read more here.
Keywords: protein; related neurodegenerative; disease; neurodegenerative diseases ... See more keywords
The contribution of CNVs to the most common aging-related neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-020-01485-4
Abstract: Alzheimer and Parkinson’s diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address… read more here.
Keywords: cnvs common; related neurodegenerative; aging related; common aging ... See more keywords
Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.145
Abstract: BACKGROUND During aging a mosaic of normal cells and cells with mitochondrial deficiency develops in various tissues including the heart. Whether this contributes to higher susceptibility for arrhythmia following myocardial infarction (MI) is unknown. METHODS… read more here.
Keywords: aging related; arrhythmia; myocardial infarction; mitochondrial dysfunction ... See more keywords