Aging related cognitive changes associated with Alzheimer's disease in Down syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.571
Abstract: Individuals with Down syndrome (DS) have an extremely high genetic risk for Alzheimer's disease (AD), however, the course of cognitive decline associated with progression to dementia is ill‐defined. Data‐driven methods can estimate long‐term trends from… read more here.
Keywords: alzheimer disease; disease; aging related; related cognitive ... See more keywords
Aging‐related prognosis analysis of definitive radiotherapy for very elderly esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1456
Abstract: Because of the exclusion for the patients more than 75 years (very elderly patients) in many clinical trials of esophageal cancer (EC), there is no consensus on prognosis and treatment for this population. We aim… read more here.
Keywords: esophageal cancer; aging related; elderly patients; cancer ... See more keywords
A risk model of 10 aging‐related genes for predicting survival and immune response in triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4674
Abstract: Accumulated studies showed that the clinical significance of aging on the development and malignancy of tumors, while the relationship between aging and the prognosis, immune response in triple‐negative breast cancer (TNBC) has not been well… read more here.
Keywords: risk model; risk; immune response; aging related ... See more keywords
SIRT6 Protects Against Myocardial Ischemia–Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-021-10184-y
Abstract: Impaired autophagic flux induces aging-related ischemia vulnerability, which is the hallmark pathology in cardiac aging. Our previous work has confirmed that the accumulation of charged multivesicular body protein 2B (CHMP2B), a subunit of the ESCRT-III… read more here.
Keywords: ischemia; accumulation; chmp2b accumulation; aging related ... See more keywords
Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00853-2
Abstract: Neurological disorders such as Alzheimer’s disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying treatments to date and now constitute a dementia crisis that affects 5 million in… read more here.
Keywords: protein; related neurodegenerative; disease; neurodegenerative diseases ... See more keywords
The contribution of CNVs to the most common aging-related neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-020-01485-4
Abstract: Alzheimer and Parkinson’s diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address… read more here.
Keywords: cnvs common; related neurodegenerative; aging related; common aging ... See more keywords
Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.145
Abstract: BACKGROUND During aging a mosaic of normal cells and cells with mitochondrial deficiency develops in various tissues including the heart. Whether this contributes to higher susceptibility for arrhythmia following myocardial infarction (MI) is unknown. METHODS… read more here.
Keywords: aging related; arrhythmia; myocardial infarction; mitochondrial dysfunction ... See more keywords
Analysis of aging-related protein interactome and cross-network module comparisons across tissues provide new insights into aging
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107506
Abstract: Delaying the human aging process and thus eliminating the risk factors for age-related diseases is one of the prime objectives. While various aging-associated genes and proteins have been characterized, which provide a significant understanding of… read more here.
Keywords: network; protein interactome; analysis; cross network ... See more keywords
Chronic exposure of zearalenone inhibits antioxidant defense and results in aging-related defects associated with DAF-16/FOXO in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117233
Abstract: Zearalenone (ZEN), a mycotoxin with endocrine disruptive activity and oxidative stress generating ability, has been a worldwide environmental concern for its prevalence and persistency. However, the long-term effect of ZEN on aging process is not… read more here.
Keywords: exposure; caenorhabditis elegans; aging related; related defects ... See more keywords
Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.12.002
Abstract: &NA; Pioglitazone (Piog) activates peroxisome proliferator activated receptor‐&ggr; (PPAR&ggr;) and is widely used in clinic for the treatment of diabetes mellitus. PPAR&ggr; in various tissues has the essential regulatory role of multiple metabolic function, suggest… read more here.
Keywords: pioglitazone; aging related; ppar ggr; mice ... See more keywords
Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.06.012
Abstract: &NA; Aging in humans represents declining in cardio‐protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between… read more here.
Keywords: aged rats; antioxidant capacity; heart; aging related ... See more keywords