Metabolic engineering of Escherichia coli for agmatine production
Sign Up to like & getrecommendations! Published in 2019 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201800104
Abstract: Agmatine is a kind of important biogenic amine. The chemical synthesis route is not a desirable choice for industrial production of agmatine. To date, there are no reports on the fermentative production of agmatine by… read more here.
Keywords: engineering; production; escherichia coli; strain ... See more keywords
Agmatine protects against sodium valproate–induced hepatic injury in mice via modulation of nuclear factor‐κB/inducible nitric oxide synthetase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22227
Abstract: Valproate is a widely used drug against epilepsy and several other neurological disorders although it has deleterious hepatotoxic side effects. The current study was designed to test if agmatine as nitric oxide modulator has protective… read more here.
Keywords: valproate; nitric oxide; factor; hepatic injury ... See more keywords
Increasing Agmatine Production in Escherichia coli through Metabolic Engineering.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b03038
Abstract: In this study, to obtain higher agmatine yields using the previously developed E. coli strain AUX4 (JM109 Δ speC Δ speF Δ speB Δ argR), the genes encoding glutamate dehydrogenase ( gdhA), glutamine synthetase (… read more here.
Keywords: coli strain; production; production escherichia; agmatine production ... See more keywords
Molecular mechanism of substrate selectivity of the arginine-agmatine Antiporter AdiC
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33963-1
Abstract: The arginine-agmatine antiporter (AdiC) is a component of an acid resistance system developed by enteric bacteria to resist gastric acidity. In order to avoid neutral proton antiport, the monovalent form of arginine, about as abundant… read more here.
Keywords: mechanism; arginine agmatine; antiporter adic; agmatine antiporter ... See more keywords
Evaluation of plasma agmatine level and its metabolic pathway in patients with bipolar disorder during manic episode and remission period
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Psychiatry in Clinical Practice"
DOI: 10.1080/13651501.2019.1569237
Abstract: Abstract Objectives: Agmatine is a cationic amine resulting from the decarboxylation of l-arginine. Agmatine has neuroprotective, anti-inflammatory, anti-stress, and anti-depressant properties. In this study, plasma agmatine, arginine decarboxylase, and agmatinase levels were measured during manic… read more here.
Keywords: remission period; bipolar disorder; episode; manic episode ... See more keywords
Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-κB Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004065
Abstract: OBJECTIVES The knowledge that agmatine is found in the human body has existed for several years; however, its role in sepsis has not yet been studied. In the present study, we investigate the role of… read more here.
Keywords: agmatine; kinase; sepsis; imidazoline receptor ... See more keywords
Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000928
Abstract: Purpose. In the cystic fibrosis (CF) airways, Pseudomonas aeruginosa undergoes diverse physiological changes in response to inflammation, antibiotic pressure, oxidative stress and a dynamic bioavailable nutrient pool. These include loss‐of‐function mutations that result in reduced… read more here.
Keywords: pseudomonas aeruginosa; agmatine accumulation; clinical isolates; aeruginosa clinical ... See more keywords
Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910688
Abstract: Atherosclerosis and NAFLD are the leading causes of death worldwide. The hallmark of NAFLD is triglyceride accumulation caused by an imbalance between lipogenesis de novo and fatty acid oxidation. Agmatine, an endogenous metabolite of arginine,… read more here.
Keywords: apoe; lipogenesis; mice; steatosis ... See more keywords
Agmatine Modulates the Phenotype of Macrophage Acute Phase after Spinal Cord Injury in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurobiology"
DOI: 10.5607/en.2017.26.5.278
Abstract: Agmatine is a decarboxylated arginine by arginine decarboxylase. Agmatine is known to be a neuroprotective agent. It has been reported that agmatine works as a NMDA receptor blocker or a competitive nitric oxide synthase inhibitor… read more here.
Keywords: cord injury; agmatine; macrophage; spinal cord ... See more keywords