Differential expression of Ago2‐mediated microRNA signaling in adipose tissue is associated with food‐induced obesity
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13471
Abstract: Adipose tissue is a major component for the regulation of energy homeostasis by storage and release of lipids. As a core element of RNA‐induced silencing complex, argonaute2 (Ago2) plays critical role in maintenance of systemic… read more here.
Keywords: ago2; expression; adipose tissue; differential expression ... See more keywords
Detection of circulating microRNAs with Ago2 complexes to monitor the tumor dynamics of colorectal cancer patients during chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31960
Abstract: Because of the different forms of circulating miRNAs in plasma, Argonaute2 (Ago2)‐miRNAs and extracellular vesicles (EV‐miRNAs), we examined the two forms of extracellular miRNAs in vitro and developed a unique methodology to detect circulating Ago2‐miRNAs… read more here.
Keywords: colorectal cancer; ago2; monitor tumor; cancer ... See more keywords
High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.009
Abstract: The identification of microRNA (miRNA) targets by Ago2 crosslinking-immunoprecipitation (CLIP) methods has provided major insights into the biology of this important class of non-coding RNAs. However, these methods are technically challenging and not easily applicable… read more here.
Keywords: high resolution; resolution vivo; mirna targets; ago2 ... See more keywords
Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
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DOI: 10.1016/j.stemcr.2017.12.023
Abstract: Summary In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA pathways exist, only Ago2 deficiency causes embryonic lethality. To investigate the role of AGO2 during mouse early development, we generated Ago2-deficient… read more here.
Keywords: embryonic stem; differentiation; ago2; mouse embryonic ... See more keywords
Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0530-7
Abstract: Argonaute2 (AGO2) is an effector of small RNA mediated gene silencing. Increasing evidence show that post-translational modifications of AGO2 can change miRNA activity at specific or global levels. Among the six mature miRNAs that are… read more here.
Keywords: 19b biogenesis; acetylation; mir 19b; mir ... See more keywords
AGO2 promotes tumor progression in KRAS-driven mouse models of non–small cell lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2026104118
Abstract: Significance RAS proteins (HRAS, NRAS, and KRAS) integrate extracellular trophic signals to promote cell proliferation. Constitutively active KRAS drives tumor initiation and progression in nonsmall cell lung cancer (NSCLC). As RAS proteins are often refractory… read more here.
Keywords: cell; cell lung; ago2; lung cancer ... See more keywords
Therapeutic role of microRNAs of small extracellular vesicles from human mesenchymal stromal/stem cells in the treatment of experimental traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0296
Abstract: Mesenchymal stem/stromal cells (MSC)-derived small extracellular vesicles (sEVs) possess therapeutic potential for treatment of traumatic brain injury (TBI). The essential role of miRNAs underlying the beneficial effects of MSC-derived sEVs for treatment of TBI remains… read more here.
Keywords: sev; ago2; role; vector ... See more keywords
Profiling of m6A RNA modifications identified an age‐associated regulation of AGO2 mRNA stability
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DOI: 10.1111/acel.12753
Abstract: Gene expression is dynamically regulated in a variety of mammalian physiologies. During mammalian aging, there are changes that occur in protein expression that are highly controlled by the regulatory steps in transcription, post‐transcription, and post‐translation.… read more here.
Keywords: m6a rna; ago2 mrna; expression; ago2 ... See more keywords
Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-1908
Abstract: T-cell prolymphocytic leukemia (T-PLL) is a chemotherapy-refractory T-cell malignancy with limited therapeutic options and a poor prognosis. Current disease concepts implicate TCL1A oncogene-mediated enhanced T-cell receptor (TCR) signaling and aberrant DNA repair as central perturbed… read more here.
Keywords: cell; ago2; non canonical; cell prolymphocytic ... See more keywords
Functional microRNA targetome undergoes degeneration-induced shift in the retina
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00478-9
Abstract: Background MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through their association with argonaute 2 (AGO2) - a key member… read more here.
Keywords: ago2; degeneration; mirna; microrna targetome ... See more keywords
No evidence for Ago2 translocation from the host erythrocyte into the Plasmodium parasite.
Sign Up to like & getrecommendations! Published in 2020 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.15852.1
Abstract: Background: Plasmodium parasites rely on various host factors to grow and replicate within red blood cells (RBC). While many host proteins are known that mediate parasite adhesion and invasion, few examples of host enzymes co-opted… read more here.
Keywords: microscopy; host; ago2; plasmodium ... See more keywords