Molecular dynamics and binding selectivity of nucleotides and polynucleotide substrates with EIF2C2/Ago2 PAZ domain.
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DOI: 10.1016/j.ijbiomac.2017.10.145
Abstract: RNA interference (RNAi) constitutes a major target in drug discovery. Recently, we reported that the Argonaute protein 2 (Ago2) PAZ domain selectively binds with all ribonucleotides except adenine and poorly recognizes deoxyribonucleotides. The binding properties… read more here.
Keywords: ago2 paz; molecular dynamics; paz domain; domain ... See more keywords