Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-020-00634-y
Abstract: Neurotoxicity caused by cisplatin is a major obstacle during chemotherapy. Oxidative stress and inflammation are considered the primary mechanism behind neuronal damage which affects the continuing chemotherapy regimen. Agomelatine was recently described as a neuroprotective… read more here.
Keywords: stress inflammation; cisplatin; neurotoxicity; cisplatin induced ... See more keywords
Evidence-Based Pharmacotherapy of Generalised Anxiety Disorder: Focus on Agomelatine
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DOI: 10.1007/s12325-021-01860-1
Abstract: Recent network meta-analyses support the use of pharmacotherapy in patients with generalised anxiety disorder (GAD). Compared with placebo, drug treatment can improve symptoms and quality of life, and is more effective in preventing relapse. Selective… read more here.
Keywords: generalised anxiety; pharmacotherapy; agomelatine; evidence based ... See more keywords
Efficacy and safety of agomelatine (10 or 25 mg/day) in non-depressed out-patients with generalized anxiety disorder: A 12-week, double-blind, placebo-controlled study
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.02.007
Abstract: Agomelatine is efficacious in reducing symptoms and preventing relapse in placebo-controlled trials in generalised anxiety disorder (GAD). Nevertheless, fixed dose studies of agomelatine in GAD have not been undertaken. To determine the minimally effective optimal… read more here.
Keywords: week; anxiety; placebo controlled; study ... See more keywords
Charles Bonnet Syndrome (CBS): Successful Treatment of Visual Hallucinations Due to Vision Loss with Agomelatine in Three Cases
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.2065
Abstract: Background CBS becomes more prevalent as the population ages. CBS is characterized by the triad of impairment of vision, complex visual hallucinations with insight, mentally normal people. Although visual hallucinations in the elderly are often… read more here.
Keywords: visual hallucinations; treatment; cbs; vision ... See more keywords
A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13902
Abstract: Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The objective of this study was… read more here.
Keywords: pharmacokinetic model; population pharmacokinetic; model agomelatine; semiphysiological population ... See more keywords
Influence of agomelatine and trastuzumab on the HER2/neu(+), MT1 (+) and MT2 (+) chemo and immunoresistant breast cancer cells lines from the previously treated patients by targeted therapy with trastuzumab.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14056
Abstract: e14056 Background: Agomelatine is a melatonin receptor agonist (MT1 and MT2) and a 5-HT2C receptor antagonist. Melatonin is a lipophilic compound that is capable of binding to cell surface receptors, cytosolic sites (calmodulin), and directly… read more here.
Keywords: cells lines; mt1 mt2; trastuzumab; agomelatine trastuzumab ... See more keywords
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.766410
Abstract: Agomelatine, an agonist of melatonergic MT1 and MT2 receptors and a selective 5-hydroxytryptamine 2C receptor antagonist, is widely applied in treating depression and insomnia symptoms in several neurogenerative diseases. However, the neuroprotective effect of agomelatine… read more here.
Keywords: agomelatine; tau phosphorylation; mice; ps1 mice ... See more keywords
The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures
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DOI: 10.3390/genes11091093
Abstract: Depression is the serious mental disorder. Previous studies suggest that the development mechanism of depression may be associated with disorders of the tryptophan catabolic pathway (TRYCAT). Thus, this study investigates the effect of agomelatine treatment… read more here.
Keywords: methylation; methylation status; brain; expression ... See more keywords