The role of intragroup agonism in parent‐offspring relationships and natal dispersal in monogamous owl monkeys (Aotus azarae) of Argentina
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Primatology"
DOI: 10.1002/ajp.22712
Abstract: Agonistic behaviors are common in many group‐living taxa and may serve a variety of functions, ranging from regulating conflicts over reproduction to defending food resources. However, high rates of agonism are not expected to occur… read more here.
Keywords: monkeys aotus; owl monkeys; agonism; aotus azarae ... See more keywords
SAR exploration of the non‐imidazole histamine H3 receptor ligand ZEL‐H16 reveals potent inverse agonism
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200451
Abstract: Histamine H3 receptor (H3R) agonists without an imidazole moiety remain very scarce. Of these, ZEL‐H16 (1) has been reported previously as a high‐affinity non‐imidazole H3R (partial) agonist. Our structure‐activity relationship analysis using derivatives of 1… read more here.
Keywords: inverse agonism; zel h16; agonism; non imidazole ... See more keywords
PPARgamma agonism inhibits progression of premalignant lesions in a murine lung squamous cell carcinoma model
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DOI: 10.1002/ijc.34210
Abstract: The N‐nitroso‐trischloroethylurea (NTCU)‐induced mouse model of squamous lung carcinoma recapitulates human disease from premalignant dysplasia through invasive tumors, making it suitable for preclinical chemoprevention drug testing. Pioglitazone is a peroxisome proliferator‐activated receptor γ (PPARγ) agonist… read more here.
Keywords: cell; dysplasia; pioglitazone; agonism ... See more keywords
Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist
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DOI: 10.1016/j.molmet.2021.101242
Abstract: Objective Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating the… read more here.
Keywords: glp gcgr; arrestin recruitment; weight loss; efficacy ... See more keywords
Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03168-4
Abstract: A computational platform, Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE… read more here.
Keywords: inflammatory bowel; agonism; ppar; dual agonism ... See more keywords
Democracy, disagreement, disruption: agonism and the environmental state
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DOI: 10.1080/09644016.2019.1684739
Abstract: ABSTRACT Contemporary liberal democratic states seem to be headed towards inevitable environmental crisis. These states are locked into unsustainable practices and appear to lack the political institutions that could help them change path. Although there… read more here.
Keywords: state; disruption agonism; disagreement disruption; agonism ... See more keywords
Aryl Hydrocarbon Receptor Agonism Antagonizes the Hypoxia-driven Inflammation in Cystic Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0196oc
Abstract: Hypoxia contributes to the exaggerated yet ineffective airway inflammation that fails to oppose infections in cystic fibrosis (CF). However, the potential for impairment of essential immune functions by the hypoxia-inducible factor (HIF)-1α inhibition demands for… read more here.
Keywords: inflammation; driven inflammation; hypoxia driven; hypoxia ... See more keywords
Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism
Sign Up to like & getrecommendations! Published in 2018 at "BMC Nephrology"
DOI: 10.1186/s12882-018-0814-8
Abstract: BackgroundOur aim was to evaluate lipid trafficking and inflammatory response of macrophages exposed to lipoproteins from subjects with moderate to severe chronic kidney disease (CKD), and to investigate the potential benefits of activating cellular cholesterol… read more here.
Keywords: kidney; hdlckd; cholesterol; agonism ... See more keywords