Immune agonist antibodies face critical test
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00214-5
Abstract: Immunotherapies that activate costimulatory receptors on T cells have failed so far in the clinic, but the first phase III trial of an agonist antibody in cancer has just begun and second-generation candidates are advancing.… read more here.
Keywords: immune agonist; agonist; critical test; antibodies face ... See more keywords
CD40 Agonist Antibodies in Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of medicine"
DOI: 10.1146/annurev-med-062518-045435
Abstract: CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist… read more here.
Keywords: medicine; cd40 agonist; cd40; cancer ... See more keywords