CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
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DOI: 10.1038/s42003-021-02293-w
Abstract: Agonist bias occurs when different ligands produce distinct signalling outputs when acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenous… read more here.
Keywords: agonist; adrenomedullin; agonist bias; receptor ... See more keywords
Fusion with Promiscuous Gα16 Subunit Reveals Signaling Bias at Muscarinic Receptors
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DOI: 10.3390/ijms221810089
Abstract: A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein classes and isoforms including non-preferential ones is essential for advanced agonist screening and drug development. Molecular crosstalk in downstream signaling… read more here.
Keywords: muscarinic receptors; agonist bias; signaling bias; bias ... See more keywords