The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.03.110
Abstract: Inflammation is a pivotal pathological factor in colorectal cancer (CRC) initiation and progression, and modulating this inflammatory state has the potential to ameliorate disease progression. NR4A receptors have emerged as key regulators of inflammatory pathways… read more here.
Keywords: agonist cytosporone; colorectal cancer; tissue; tissue vivo ... See more keywords
NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.339492
Abstract: Nuclear receptor subfamily 4 group A1 (NR4A1) is an orphan nuclear receptor, which is expressed in the majority of cells. NR4A1 expression in peripheral blood mononuclear cells is low during the preclinical stage of multiple… read more here.
Keywords: sclerosis; model multiple; agonist cytosporone; multiple sclerosis ... See more keywords