Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs
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DOI: 10.1038/s41467-025-61932-6
Abstract: The family of ρ-type GABAA receptors includes potential therapeutic targets in several neurological conditions, and features distinctive pharmacology compared to other subtypes. Here we combine structures, recordings and simulations to characterize the binding and conformational… read more here.
Keywords: agonist drugs; structures gabaa; cryo structures; antagonist agonist ... See more keywords
Trk agonist drugs rescue noise-induced hidden hearing loss
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DOI: 10.1172/jci.insight.142572
Abstract: TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro… read more here.
Keywords: trk agonist; treatment; agonist drugs; noise induced ... See more keywords