Mitochondrion‐Targeted Type I Photodynamic Therapy for Agonist Independent cGAS‐STING Activation
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DOI: 10.1002/adma.202418894
Abstract: CGAS‐STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion‐targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)‐derived type I photosensitizer (BDP) and Au nanoparticle‐engineered hollow mesoporous silica (HMSN/AuNPs) has… read more here.
Keywords: cgas; agonist independent; mitochondrion targeted; independent cgas ... See more keywords
Glucocorticoid Receptor β Overexpression Has Agonist-Independent Insulin-Mimetic Effects on HepG2 Glucose Metabolism
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DOI: 10.3390/ijms23105582
Abstract: Glucocorticoids (GC) are steroids hormones that drive circulating glucose availability through gluconeogenesis in the liver. However, alternative splicing of the GR mRNA produces two isoforms, termed GRα and GRβ. GRα is the classic receptor that… read more here.
Keywords: independent insulin; overexpression; agonist independent; insulin mimetic ... See more keywords