Aspirin eugenol ester inhibits agonist‐induced platelet aggregation in vitro by regulating PI3K/Akt, MAPK and Sirt 1/CD40L pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.02.032
Abstract: ABSTRACT Aspirin eugenol ester (AEE) was a promising drug candidate for treating inflammation, pain and fever and preventing cardiovascular diseases with fewer side effects than its precursors. Previous researches indicated that AEE could markedly inhibit… read more here.
Keywords: platelet aggregation; induced platelet; agonist induced; aggregation vitro ... See more keywords
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00253-9
Abstract: G protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors. They can exist and act as dimers, but the requirement of dimers for agonist-induced signal initiation and structural dynamics remains largely unknown. Frizzled… read more here.
Keywords: dimer dissociation; dissociation; protein coupled; coupled receptor ... See more keywords
Inhibition of agonist-induced platelet aggregation by magnesium sulfate warrants its use as an alternative in vitro anticoagulant in pseudothrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Platelets"
DOI: 10.1080/09537104.2019.1663804
Abstract: Abstract MgSO4 is effective in preventing spontaneous in vitro platelet agglutination in anticoagulant-induced pseudothrombocytopenia (PTCP). In order to learn more about its potential as an in vitro anticoagulant, platelets from MgSO4-anticoagulated blood were stimulated by… read more here.
Keywords: induced platelet; aggregation; vitro anticoagulant; platelet aggregation ... See more keywords
Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00948.2016
Abstract: Pituitary corticotrophs fire action potentials spontaneously and in response to stimulation with corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), and such electrical activity is critical for calcium signaling and calcium-dependent adrenocorticotropic hormone secretion. These cells… read more here.
Keywords: pituitary corticotrophs; electrical activity; crh avp; agonist induced ... See more keywords
ROS and DNA repair in spontaneous versus agonist-induced NETosis: Context matters
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1033815
Abstract: Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis). Nevertheless, how ROS induces NETosis at baseline and during neutrophil activation is unknown. Although neutrophils carry DNA transcription, replication and repair machineries, their… read more here.
Keywords: dna repair; induced netosis; agonist induced; repair ... See more keywords