Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism
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DOI: 10.7554/elife.69061
Abstract: The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the physiological importance of autocatalytic cleavage upstream of the agonistic… read more here.
Keywords: agonist mediated; tethered agonist; adhesion gpcr; gpr116 ... See more keywords