Abstract CT096: Phase 1 study of RO7119929 (TLR7 agonist prodrug) in patients (pts) with advanced primary or metastatic liver cancers
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DOI: 10.1158/1538-7445.am2023-ct096
Abstract: Background Agonists for TLR7, a major regulator of the innate immune response, have been tested in oncology across several nonclinical and clinical investigations due to their ability to stimulate T-cell mediated cancer cell killing. The… read more here.
Keywords: liver cancers; agonist prodrug; crs; study ... See more keywords
A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma
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DOI: 10.2147/jaa.s151849
Abstract: Background Purinergic receptors control cell proliferation, apoptosis, migration, inflammation, and cytokine secretion. Increased expression of specific purinergic receptors is reported in asthma. The role of purinergic P2Y6 receptors (P2Y6R) in asthma is controversial. Hypothesis P2Y6R… read more here.
Keywords: purinergic p2y6; inflammation; agonist prodrug; gc021109 ... See more keywords