Potentiation of a neuronal nicotinic receptor via pseudo-agonist site
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DOI: 10.1007/s00018-018-2993-7
Abstract: Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)3(β2)2 and (α4)2(β2)3, each with distinct pharmacological signatures; (α4)3(β2)2 receptors are strongly potentiated by the drug NS9283, whereas (α4)2(β2)3 receptors are unaffected.… read more here.
Keywords: neuronal nicotinic; pseudo agonist; agonist site; receptor ... See more keywords