Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels
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DOI: 10.7554/elife.51423
Abstract: Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is… read more here.
Keywords: pore channels; voltage; two pore; agonist specific ... See more keywords