A simple model for the assessment of the agonistic activity of dibenzazepine derivatives by molecular moieties
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02654-w
Abstract: A simple approach is introduced to assess the agonistic activity of dibenzazepine derivatives including 11 H -dibenz[ b , e ]azepine and the dibenz[ b , f ][1,4]oxazepine derivatives. Dibenzazepine derivatives show extremely potent activators… read more here.
Keywords: activity dibenzazepine; molecular moieties; agonistic activity; activity ... See more keywords
Telmisartan ameliorates dextran sodium sulfate-induced colitis in rats by modulating NF-κB signalling in the context of PPARγ agonistic activity.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.07.014
Abstract: Variations in Nrf-2 and NF-κB expression profiles have been reported in ulcerative colitis (UC), in which an interplay between these two critical pathways has been identified. The therapeutic potential of angiotensin receptor blockers (ARBs) for… read more here.
Keywords: tel; colitis; ppar agonistic; agonistic activity ... See more keywords
New insights into potential estrogen agonistic activity of triazole fungicides and coupled metabolic disturbance.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.127479
Abstract: Triazole fungicides are highly effective pesticides widely used in plant protection, which has caused potential hazards to human health and ecological safety. To fully understand their potential hepatotoxicity, we first analyzed the transcriptome profiles in… read more here.
Keywords: new insights; estrogen; triazole fungicides; agonistic activity ... See more keywords
Antimicrobial Triclocarban Exhibits Higher Agonistic Activity on Estrogen-Related Receptor γ than Triclosan at Human Exposure Levels: A Novel Estrogenic Disruption Mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Technology Letters"
DOI: 10.1021/acs.estlett.0c00338
Abstract: Triclosan (TCS) and triclocarban (TCC) are two widely used antimicrobial agents that have been reported to be estrogenic disruptors. Previous researches have shown that TCC and TCS exhibit weak or ... read more here.
Keywords: antimicrobial triclocarban; exhibits higher; triclocarban; triclocarban exhibits ... See more keywords
TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
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DOI: 10.1038/s42003-021-02309-5
Abstract: Monoclonal antibodies (mAb) and natural ligands targeting costimulatory tumor necrosis factor receptors (TNFR) exhibit a wide range of agonistic activities and antitumor responses. The mechanisms underlying these differential agonistic activities remain poorly understood. Here, we… read more here.
Keywords: receptor clusters; receptor clustering; differential agonistic; agonistic activity ... See more keywords
Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1148513
Abstract: Introduction Limitation of pharmaceutical application of resveratrol (RSV) and piceatannol (PIC) continue to exist, there is a need to obtain the superior analogs of two stilbenes with promoted activity, stability, and bioavailability. Microbial transformation has… read more here.
Keywords: agonistic activity; activity; gpr119 agonistic; microbial biotransformation ... See more keywords