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Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering

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1 Published in 2022 at "Communications Biology"

DOI: 10.1038/s42003-022-03182-6

Abstract: Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel panel of CD27 mAb… read more here.

Keywords: receptor clustering; engineering; agonistic cd27; cd27 ... See more keywords