Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
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DOI: 10.1016/j.celrep.2021.109648
Abstract: Summary Metabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors activated by the main excitatory neurotransmitter, L-glutamate. mGluR activation by agonists binding in the venus flytrap domain is regulated by positive (PAM) or negative (NAM) allosteric… read more here.
Keywords: metabotropic glutamate; allosteric modulators; agonists allosteric; receptor ... See more keywords