Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-61663-2_7
Abstract: The cannabinoids are a family of chemical compounds that can be either synthesized or naturally derived. These compounds have been shown to modulate a wide variety of biological processes. In this chapter, the studies detailing… read more here.
Keywords: laboratory animals; cannabinoid agonists; agonists antagonists; effects cannabinoid ... See more keywords
Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-017-3419-4
Abstract: Nicotinic acetylcholine receptors (nAChRs) belong to the Cys-loop receptor family and are important drug targets for the treatment of neurological diseases. However, the precise determinants of the binding efficacies of ligands for these receptors are… read more here.
Keywords: energy profiles; binding energy; agonists partial; agonists antagonists ... See more keywords
Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.10.018
Abstract: In androgenetic alopecia, androgens impair dermal papilla-induced hair follicle stem cell (HFSC) differentiation inhibiting Wnt signaling. Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) stimulation in androgen-sensitive dermal papilla cells (DPC) cultured as spheroids or… read more here.
Keywords: hfsc differentiation; wnt agonists; differentiation; agonists antagonists ... See more keywords
Neonatal exposure to agonists and antagonists of sex steroid receptors induces changes in the expression of oocyte-derived growth factors and their receptors in ovarian follicles in gilts.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.05.018
Abstract: The objective of the present study was to examine the effects of neonatal exposure to either agonists or antagonists of androgen and estrogen receptors on the expression of growth and differentiation factor 9 (GDF9) and… read more here.
Keywords: bmp15; ovarian follicles; agonists antagonists; bmpr2 ... See more keywords
Agonists and Antagonists Show Different Unbinding Paths from the TLR8 Receptor
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.5c00496
Abstract: Toll-like receptors (TLRs) form the first barrier of the innate immune system. TLR8 is an important target to treat autoimmune diseases since its ligand-induced degree of activation regulates immune response and associated hyperinflammation. Molecular dynamics… read more here.
Keywords: receptor; antagonists show; different unbinding; show different ... See more keywords
A Unified Deep Graph Model for Identifying the Molecular Categories of Ligands Targeting Nuclear Receptors
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5c00700
Abstract: To fulfill functions for differentially regulating the downstream signaling pathways, functional ligands (i.e., agonists or antagonists) targeting nuclear receptors (NRs) are designed to stabilize different conformations (active or inactive) of the proteins. However, in practical… read more here.
Keywords: deep graph; unified deep; nuclear receptors; model ... See more keywords
Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01624
Abstract: Highly selective dopamine D3 receptor (D3R) partial agonists/antagonists have been developed for the treatment of psychostimulant use disorders (PSUD). However, none have reached the clinic due to insufficient potency/efficacy or potential cardiotoxicity. Cariprazine, an FDA-approved… read more here.
Keywords: partial agonists; dopamine receptor; agonists antagonists; treatment psychostimulant ... See more keywords
Analysing the effect caused by increasing the molecular volume in M1-AChR receptor agonists and antagonists: a structural and computational study
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d3ra07380g
Abstract: M1 muscarinic acetylcholine receptor (M1-AChR), a member of the G protein-coupled receptors (GPCR) family, plays a crucial role in learning and memory, making it an important drug target for Alzheimer's disease (AD) and schizophrenia. M1-AChR… read more here.
Keywords: receptor; effect caused; analysing effect; agonists antagonists ... See more keywords
Considerations for the use of gonadotropin‐releasing hormone agonists and antagonists in patients with prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Urology"
DOI: 10.1111/iju.14303
Abstract: Prostate cancer is the second most common cause of cancer‐related deaths in men, representing a major source of morbidity and mortality. Androgen deprivation therapy is the primary treatment for patients with advanced prostate cancer at… read more here.
Keywords: releasing hormone; gonadotropin releasing; prostate cancer; agonists antagonists ... See more keywords
Expression of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after non-surgical periodontal treatment: A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.13029
Abstract: Periodontitis is a preventable and treatable multifactorial chronic inflammatory disease that can lead to irreversible periodontal destruction and tooth loss. Wnt signaling and its regulators play an important role in periodontal inflammation, destruction, regeneration, and… read more here.
Keywords: signaling agonists; periodontal treatment; non surgical; agonists antagonists ... See more keywords
Multitargeting nature of muscarinic orthosteric agonists and antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.974160
Abstract: Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or… read more here.
Keywords: multitargeting nature; agonists antagonists; physiology; nature muscarinic ... See more keywords