5-Alkoxy-1-aryl-3-polyfluoroalkylpyrazoles with Antinociceptive Activity: Partial Agonists of TRPV1 Ion Channels.
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DOI: 10.1002/cmdc.202300063
Abstract: Chemoselective O-alkylation of 1-aryl-3-polyfluoroalkylpyrazol-5-oles under basic conditions resulted in a series of 5-alkoxypyrazoles (26 derivatives). They were showed to have an acceptable ADME profile (in silico). In experiments in vivo (CD-1 mice), it was found… read more here.
Keywords: partial agonists; trpv1 ion; agonists trpv1; aryl polyfluoroalkylpyrazoles ... See more keywords