Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity
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DOI: 10.1080/15476286.2017.1328349
Abstract: ABSTRACT Short hairpin RNAs (shRNAs) are widely used for gene silencing by the RNA interference (RNAi) mechanism. The shRNA precursor is processed by the Dicer enzyme into active small interfering RNAs (siRNAs) that subsequently target… read more here.
Keywords: loop size; influence loop; agoshrna; activity ... See more keywords
Analysis of AgoshRNA maturation and loading into Ago2
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DOI: 10.1371/journal.pone.0183269
Abstract: The RNA interference (RNAi) pathway was recently expanded by the discovery of multiple alternative pathways for processing of natural microRNA (miRNA) and man-made short hairpin RNA (shRNA) molecules. One non-canonical pathway bypasses Dicer cleavage and… read more here.
Keywords: loading ago2; agoshrna maturation; analysis agoshrna; agoshrna ... See more keywords