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   Articles with "agr bgr" as a keyword



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Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test

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recommendations! Published in 2019 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2018.12.027

Abstract: HIGHLIGHTSRole of nicotinic receptors was tested in the antidepressant effects of bupropion.&agr;4, &agr;5, &agr;6, and &bgr;2 nicotinic receptor subunit WT&KO mice were studied using the FST.&agr;4, &agr;6, and &bgr;2 subunits modulate the antidepressant‐like effects of… read more here.

Keywords: agr bgr; agr; mice; agr agr ... See more keywords
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Inhibition of osteoporosis by the &agr;v&bgr;3 integrin antagonist of rhodostomin variants

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recommendations! Published in 2017 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2017.03.019

Abstract: Abstract Integrins are heterodimeric cell surface receptors that mediate cell–cell and cell–matrix interaction. The vitronectin and osteopontin receptor &agr;v&bgr;3 integrin has increased expression levels and is implicated in the adhesion, activation, and migration of osteoclasts… read more here.

Keywords: hsa arlddl; agr bgr; cell; bgr integrin ... See more keywords
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Shogaol but not gingerol has a neuroprotective effect on hemorrhagic brain injury: Contribution of the &agr;, &bgr;‐unsaturated carbonyl to heme oxygenase‐1 expression

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recommendations! Published in 2019 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.10.029

Abstract: Abstract We investigated the effects of shogaol, which has an &agr;, &bgr;‐unsaturated carbonyl group, and gingerol, which does not, on primary‐cultured microglia to understand how the &agr;, &bgr;‐unsaturated carbonyl interacts with Kelch‐like ECH‐associated protein (Keap)1.… read more here.

Keywords: agr bgr; heme oxygenase; bgr unsaturated; unsaturated carbonyl ... See more keywords
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Quantification and modeling of nanomechanical properties of chlorpropamide &agr;, &bgr;, and &ggr; conformational polymorphs

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recommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.06.013

Abstract: Abstract The nanomechanical properties of the &agr;‐, &bgr;‐, and &ggr;‐ conformational polymorphs of chlorpropamide were determined by the dynamic contact module continuous stiffness measurement at nanoindenter. The mechanical anisotropy of the &agr;‐polymorph was confirmed by… read more here.

Keywords: agr bgr; conformational polymorphs; bgr ggr; nanomechanical properties ... See more keywords
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Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3+ &agr;&bgr; T‐cells

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recommendations! Published in 2017 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2017.10.013

Abstract: HighlightsThe Notch activation may be cis or trans ligand‐dependent which are regulated by TCR signalling on human &agr;&bgr; T cells.Notch signalling has the ability to affect both the proximal and distal TCR signalling events.Inhibition of… read more here.

Keywords: notch signalling; agr bgr; bgr cells; tcr signalling ... See more keywords
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In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens

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recommendations! Published in 2017 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2017.09.020

Abstract: ABSTRACT &agr;‐Conotoxins inhibit nicotinic acetylcholine receptors (nAChRs) and are used as probes to study cholinergic pathways in vertebrates. Model organisms, such as Drosophila melanogaster, express nAChRs in their CNS that are suitable to investigate the… read more here.

Keywords: pic pic; agr; agr bgr; agr conotoxins ... See more keywords
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Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry

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recommendations! Published in 2019 at "Pharmacological Research"

DOI: 10.1016/j.phrs.2018.11.031

Abstract: &NA; Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the &agr;4 and &bgr;2 subunits of the nicotinic acetylcholine… read more here.

Keywords: epilepsy; bgr; agr bgr; bgr receptors ... See more keywords
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Pre‐clinical evaluation of voltage‐gated calcium channel blockers derived from the spider P. nigriventer in glioma progression

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recommendations! Published in 2017 at "Toxicon"

DOI: 10.1016/j.toxicon.2017.02.001

Abstract: Abstract This study investigated the effects of P/Q‐ and N‐type voltage‐gated calcium channel (VGCC) blockers derived from P. nigriventer in glioma progression, by means of in vitro and in vivo experiments. Glioma cells M059J, U‐138MG… read more here.

Keywords: agr bgr; glioma; type vgcc; gated calcium ... See more keywords
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Integrin &agr;M&bgr;2 is differently expressed by subsets of human osteoclast precursors and mediates adhesion of classical monocytes to bone

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recommendations! Published in 2017 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2016.11.018

Abstract: Abstract Bone‐degrading osteoclasts are formed through fusion of their monocytic precursors. In the population of human peripheral blood monocytes, three distinct subsets have been identified: classical, intermediate and non‐classical monocytes. We have previously shown that… read more here.

Keywords: agr bgr; integrin agr; bone; osteoclast precursors ... See more keywords
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Does the clinical phenotype of mucolipidosis-III&ggr; differ from its &agr;&bgr; counterpart?: supporting facts in a cohort of 18 patients

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recommendations! Published in 2019 at "Clinical Dysmorphology"

DOI: 10.1097/mcd.0000000000000249

Abstract: Mucolipidosis-III&ggr; (ML-III&ggr;) is a recessively inherited slowly progressive skeletal dysplasia caused by mutations in GNPTG. We report the genetic and clinical findings in the largest cohort with ML-III&ggr; so far: 18 affected individuals from 12… read more here.

Keywords: agr bgr; mucolipidosis iii; ggr; cohort ... See more keywords
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A high mucosal blocking score is associated with HIV protection

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recommendations! Published in 2019 at "AIDS"

DOI: 10.1097/qad.0000000000002099

Abstract: Background: Early steps of HIV infection are mediated by the binding of the envelope to mucosal receptors as &agr;4&bgr;7 and the C-type lectins DC-SIGN and langerin. Previously Env-specific B-cell responses have been reported in highly… read more here.

Keywords: agr bgr; hiv; blocking score; sign ... See more keywords