In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.09.020
Abstract: ABSTRACT &agr;‐Conotoxins inhibit nicotinic acetylcholine receptors (nAChRs) and are used as probes to study cholinergic pathways in vertebrates. Model organisms, such as Drosophila melanogaster, express nAChRs in their CNS that are suitable to investigate the… read more here.
Keywords: pic pic; agr; agr bgr; agr conotoxins ... See more keywords
Discovery and characterization of EIIB, a new &agr;‐conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI‐TOF/TOF mass spectrometry
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DOI: 10.1016/j.toxicon.2017.02.023
Abstract: &NA; Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by &agr;‐conotoxins, a family of peptide toxins… read more here.
Keywords: methodology; tof tof; maldi tof; tof ... See more keywords