Translational repression of HIF2&agr; expression in mice with Chuvash polycythemia reverses polycythemia
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DOI: 10.1172/jci97684
Abstract: Chuvash polycythemia is an inherited disease caused by a homozygous germline VHLR200W mutation, which leads to impaired degradation of HIF2&agr;, elevated levels of serum erythropoietin, and erythrocytosis/polycythemia. This phenotype is recapitulated by a mouse model… read more here.
Keywords: hif2 agr; agr expression; mice; polycythemia ... See more keywords