Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
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DOI: 10.1016/j.neuropharm.2018.07.009
Abstract: ABSTRACT Several previous studies have demonstrated that the activity of neurotransmitters acting on ligand‐gated ion channels such as the nicotinic acetylcholine receptor (nAChR) can be altered by compounds binding to allosteric modulatory sites. In the… read more here.
Keywords: positive negative; negative allosteric; nicotinic acetylcholine; allosteric modulators ... See more keywords
Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists
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DOI: 10.1016/j.neuropharm.2018.07.019
Abstract: ABSTRACT Peptide and protein neurotoxins, such as &agr;‐conotoxins from Cone snails and &agr;‐neurotoxins from snake venoms, are excellent tools to identify distinct nicotinic acetylcholine receptor (nAChR) subtypes. Here we compared the rat/human species specificity of… read more here.
Keywords: k11a txib; peptide protein; txib h5d; species specificity ... See more keywords
Roles of Nicotine in the Development of Intracranial Aneurysm Rupture
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DOI: 10.1161/strokeaha.118.021706
Abstract: Background and Purpose— Tobacco cigarette smoking is considered to be a strong risk factor for intracranial aneurysmal rupture. Nicotine is a major biologically active constituent of tobacco products. Nicotine’s interactions with vascular cell nicotinic acetylcholine… read more here.
Keywords: intracranial aneurysm; rupture; agr nachr; aneurysm rupture ... See more keywords