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   Articles with "agr syn" as a keyword



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Development of a Biochemical Diagnosis of Parkinson Disease by Detection of &agr;-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

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recommendations! Published in 2017 at "JAMA Neurology"

DOI: 10.1001/jamaneurol.2016.4547

Abstract: Importance Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative disease associated with the accumulation of misfolded &agr;-synuclein (&agr;Syn) aggregates. An important problem in this disease is the lack of a sensitive, specific, and… read more here.

Keywords: diagnosis; syn pmca; disease; agr syn ... See more keywords
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Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson’s disease

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recommendations! Published in 2018 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2017.11.025

Abstract: HIGHLIGHTSTransgenic mice overexpressing human &agr;‐Syn under the control of the mouse Thy1‐promotor.Three transgenic lines express similar levels of &agr;‐Syn mRNA but a different number of cells expressing human &agr;‐syn.L62 has greatest level of aggregated &agr;‐Syn… read more here.

Keywords: agr syn; syn; mice; parkinson disease ... See more keywords
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Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.11.010

Abstract: ABSTRACT Accumulation of alpha‐synuclein (&agr;‐syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and… read more here.

Keywords: agr syn; ccr2; neurodegeneration; parkinson disease ... See more keywords
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Impact of DHA intake in a mouse model of synucleinopathy

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.12.002

Abstract: ABSTRACT Polyunsaturated fatty acids omega‐3 (n‐3 PUFA), such as docosahexaenoic acid (DHA), have been shown to prevent, and partially reverse, neurotoxin‐induced nigrostriatal denervation in animal models of Parkinson's disease (PD). However, the accumulation of &agr;‐synuclein… read more here.

Keywords: agr; thy1 agr; mice; agr syn ... See more keywords