α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.09.001
Abstract: ABSTRACT Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the formation of &agr;‐synuclein‐containing protein aggregates called Lewy bodies within the brain. A crucial role for &agr;‐synuclein in the pathogenesis… read more here.
Keywords: synuclein; copy; disease; agr synuclein ... See more keywords
Environmental neurotoxicant manganese regulates exosome‐mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to &agr;‐synuclein misfolding in metal neurotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.04.007
Abstract: Graphical abstract Figure. No caption available. HighlightsExposure to an environmental neurotoxin, Mn, can actively modulate exosome RNA cargo.Mn induces Rab27a to increase extracellular RNA via exosomes.Mn treatment alters exosomal small RNA profiling.Mn upregulates several miRNAs… read more here.
Keywords: agr; extracellular mirnas; parkinson disease; agr synuclein ... See more keywords
LncRNA SNHG1 promotes &agr;‐synuclein aggregation and toxicity by targeting miR‐15b‐5p to activate SIAH1 in human neuroblastoma SH‐SY5Y cells
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DOI: 10.1016/j.neuro.2017.12.001
Abstract: HighlightsSNHG1 is upregulated and miR‐15b‐5p is downregulated in PD.SIAH1 promotes &agr;‐synuclein aggregation and toxicity.SIAH1 is a target gene of miR‐15b‐5p.SNHG1 is able to directly bind to miR‐15‐5p and represses miR‐15‐5p expression.SNHG1 promotes &agr;‐synuclein aggregation and… read more here.
Keywords: synuclein aggregation; snhg1; mir 15b; siah1 ... See more keywords
Glycation potentiates &agr;-synuclein-associated neurodegeneration in synucleinopathies
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DOI: 10.1093/brain/awx056
Abstract: α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings of… read more here.
Keywords: synuclein; potentiates agr; synuclein associated; glycation potentiates ... See more keywords