Flavoxanthin Binds to AGR2 to Mediate Fatty Acid Oxidation and Reinforce Anoikis in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70129
Abstract: Traditional Chinese medicine (TCM) can not only alleviate symptoms in cancer patients and improve their life quality but also serve as an adjuvant therapy to reduce the toxic side effects of chemotherapy and radiotherapy, making… read more here.
Keywords: acid oxidation; agr2; luad; medicine ... See more keywords
AGR2-AGR3 hetero-oligomeric complexes: Identification and characterization.
Sign Up to like & getrecommendations! Published in 2021 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2021.107808
Abstract: In this paper we compare electrochemical behavior of two homolog proteins, namely anterior gradient 2 (AGR2) and anterior gradient 3 (AGR3), playing an important role in cancer cell biology. The slight variation in their protein… read more here.
Keywords: agr2 agr3; agr2; complexes identification; agr3 hetero ... See more keywords
The role of the XBP-1/AGR2 signaling pathway in the regulation of airway Mucin5ac hypersecretion under hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.05.023
Abstract: Oversecretion of Mucin5ac (MUC5AC), which is primarily synthesized by goblet cells and is the major gel-forming mucin, is a hallmark of various pulmonary inflammatory diseases. Hypoxia is considered a common pathophysiologic feature in various pulmonary… read more here.
Keywords: hif; agr2; muc5ac hypersecretion; hypersecretion ... See more keywords
Anterior gradient 2 is involved in the post-transcriptional regulation of β-dystroglycan
Sign Up to like & getrecommendations! Published in 2021 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2020.1871405
Abstract: ABSTRACT Anterior gradient 2 (AGR2) is a protein disulfide isomerase over-expressed in numerous types of cancer. Although AGR2 plays a role in ER homeostasis, its function(s) in tumorigenesis is still elusive. Here we demonstrate that… read more here.
Keywords: agr2; anterior gradient; cytoskeletal network; expression ... See more keywords
Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc–xCT
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325137
Abstract: Objective Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute to colorectal cancer (CRC) metastasis. We investigated the cellular… read more here.
Keywords: metastasis; cd98hc xct; agr2; crc ... See more keywords
A High-Affinity Monoclonal Antibody Against the Pancreatic Ductal Adenocarcinoma Target, Anterior Gradient-2 (AGR2/PDIA17)
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DOI: 10.3390/antib13040101
Abstract: Background/Objectives: Anterior Gradient-2 (AGR2/PDIA17) is a member of the protein disulfide isomerase (PDI) family of oxidoreductases. AGR2 is up-regulated in several solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Given the dire need for new therapeutic… read more here.
Keywords: high affinity; gradient agr2; affinity; agr2 ... See more keywords
Potential Role of AGR2 for Mammalian Skin Wound Healing
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097895
Abstract: The limited ability of mammals to regenerate has garnered significant attention, particularly in regard to skin wound healing (WH), which is a critical step for regeneration. In human adults, skin WH results in the formation… read more here.
Keywords: skin; wound healing; agr2; role ... See more keywords