AGR2-AGR3 hetero-oligomeric complexes: Identification and characterization.
Sign Up to like & getrecommendations! Published in 2021 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2021.107808
Abstract: In this paper we compare electrochemical behavior of two homolog proteins, namely anterior gradient 2 (AGR2) and anterior gradient 3 (AGR3), playing an important role in cancer cell biology. The slight variation in their protein… read more here.
Keywords: agr2 agr3; agr2; complexes identification; agr3 hetero ... See more keywords
The role of the XBP-1/AGR2 signaling pathway in the regulation of airway Mucin5ac hypersecretion under hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.05.023
Abstract: Oversecretion of Mucin5ac (MUC5AC), which is primarily synthesized by goblet cells and is the major gel-forming mucin, is a hallmark of various pulmonary inflammatory diseases. Hypoxia is considered a common pathophysiologic feature in various pulmonary… read more here.
Keywords: hif; agr2; muc5ac hypersecretion; hypersecretion ... See more keywords
Anterior gradient 2 is involved in the post-transcriptional regulation of β-dystroglycan
Sign Up to like & getrecommendations! Published in 2021 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2020.1871405
Abstract: ABSTRACT Anterior gradient 2 (AGR2) is a protein disulfide isomerase over-expressed in numerous types of cancer. Although AGR2 plays a role in ER homeostasis, its function(s) in tumorigenesis is still elusive. Here we demonstrate that… read more here.
Keywords: agr2; anterior gradient; cytoskeletal network; expression ... See more keywords
Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc–xCT
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325137
Abstract: Objective Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute to colorectal cancer (CRC) metastasis. We investigated the cellular… read more here.
Keywords: metastasis; cd98hc xct; agr2; crc ... See more keywords
Potential Role of AGR2 for Mammalian Skin Wound Healing
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097895
Abstract: The limited ability of mammals to regenerate has garnered significant attention, particularly in regard to skin wound healing (WH), which is a critical step for regeneration. In human adults, skin WH results in the formation… read more here.
Keywords: skin; wound healing; agr2; role ... See more keywords