Heparin Increases Food Intake through AgRP Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.08.049
Abstract: SUMMARY Although the widely used anticoagulant drug heparin has been shown to have many other biological functions independent of its anticoagulant role, its effects on energy homeostasis are unknown. Here, we demonstrate that heparin level… read more here.
Keywords: heparin increases; food intake; increases food; agrp neurons ... See more keywords
Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.07.008
Abstract: Objective The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce body weight. As such, liraglutide is growing in popularity in the treatment of diabetes and chronic… read more here.
Keywords: pomc neurons; npy agrp; pomc npy; agrp neurons ... See more keywords
AgRP neurons trigger long-term potentiation and facilitate food seeking
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-01161-1
Abstract: Sufficient feeding is essential for animals’ survival, which requires a cognitive capability to facilitate food seeking, but the neurobiological processes regulating food seeking are not fully understood. Here we show that stimulation of agouti-related peptide-expressing… read more here.
Keywords: long term; facilitate food; agrp neurons; food seeking ... See more keywords
The Asprosin–OLFR734 module regulates appetitive behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-0152-4
Abstract: Dear Editor, Organisms need to maintain the balance between energy intake and expenditure for healthy survival. For mammals, eating is the most common process to fuel the body, and ingestive behaviors are well controlled by… read more here.
Keywords: asprosin; olfr734; olfr734 mice; agrp neurons ... See more keywords
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05711-6
Abstract: Abstractp53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide… read more here.
Keywords: diet induced; p53 agrp; induced obesity; agrp neurons ... See more keywords
Regulation of substrate utilization and adiposity by Agrp neurons
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08239-x
Abstract: The type of nutrient utilized by the organism at any given time—substrate utilization—is a critical component of energy metabolism. The neuronal mechanisms involved in the regulation of substrate utilization in mammals are largely unknown. Here,… read more here.
Keywords: substrate utilization; regulation substrate; utilization; agrp neurons ... See more keywords
NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14291-3
Abstract: Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding and insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY)-dependent signaling to the diverse physiological consequences of activating AgRP neurons. NPY-deficient mice fail to rapidly… read more here.
Keywords: rapid feeding; neurons npy; npy deficient; agrp neurons ... See more keywords
Genetic identification of leptin neural circuits in energy and glucose homeostases
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0049-7
Abstract: Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel status, suppress appetite following a meal, promote energy expenditure and maintain blood glucose stability1,2. Dysregulation of leptin or its receptors… read more here.
Keywords: energy; leptin; agrp neurons; neural circuits ... See more keywords
Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93378-3
Abstract: Glucocorticoids (GCs) are widely prescribed anti-inflammatory medicines, but their use can lead to metabolic side-effects. These may occur through direct actions of GCs on peripheral organs, but could also be mediated by the hypothalamic AgRP… read more here.
Keywords: part; treatment; agrp mice; cort ... See more keywords
A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300015120
Abstract: Significance Anorexia nervosa is a life-threatening psychiatric illness with poorly understood cellular and molecular mechanisms and limited treatment options. Emerging evidence points to the importance of hypothalamic agouti-related peptide (AgRP) neurons in anorexia nervosa, but… read more here.
Keywords: anorexia nervosa; small molecule; treatment; anorexia ... See more keywords
Agouti‐related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13190
Abstract: Agouti‐related peptide (AgRP) neurons are thought to indirectly regulate the activity of hypothalamic gonadotrophin‐releasing hormone neurons which control fertility. AgRP neurons also drive caloric intake and are modulated by metabolically‐relevant hormones, providing a link to… read more here.
Keywords: agrp neurons; agouti related; related peptide; male mice ... See more keywords