Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20210072
Abstract: In spite of the fact that the modulatory effects of angiotensin II (Ang II) on the sympathetic nerve activity to targeted organs involved in blood pressure (BP) regulation is well acknowledged, the local production of… read more here.
Keywords: erythropoiesis; ang; agt; cardiovascular homeostasis ... See more keywords
A3938 Renal angiotensin generation depends on hepatic angiotensinogen (AGT): evidence from a preclinical study with liver-targeted AGT small interfering RNA (siRNA)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548083.79380.91
Abstract: Objectives: AGT synthesis is believed to occur in liver, kidney, brain and adipocytes, so that selectively deleting hepatic AGT may not alter renal angiotensin (Ang) levels. Here we investigated whether arterial pressure lowering with liver-targeted… read more here.
Keywords: liver targeted; valsartan; targeted agt; agt ... See more keywords
Abstract P2030: DOCA-Salt Diminishes Brain RAS Activity In Parallel With Plasma And Renal RAS Activity - No Evidence For Selective Brain RAS Activation
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2030
Abstract: Deoxycorticosterone acetate (DOCA)-salt is suggested to increase blood pressure via selective upregulation of the brain renin-angiotensin system (RAS), while suppressing the circulating RAS. Yet, we have observed parallel downregulation of plasma and brain renin in… read more here.
Keywords: doca salt; brain ras; agt; ang ... See more keywords
The Relationship between the Intrarenal Dopamine System and Intrarenal Renin-angiotensin System Depending on the Renal Function
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DOI: 10.2169/internalmedicine.0994-18
Abstract: Objective The mechanisms underlying the intrarenal renin-angiotensin system (RAS) activation depend on the conditions of kidney diseases. In angiotensin II (AngII) infusion models, the circulating AngII is filtered into the renal tubular lumens, activating intrarenal… read more here.
Keywords: intrarenal ras; intrarenal dopamine; system; dopamine ... See more keywords
The Urinary Angiotensinogen to Urinary Albumin Ratio Reflects Whether the Renin-angiotensin System in the Kidney Is Activated due to Filtration of Plasma Angiotensinogen through the Damaged Glomeruli or the Production of Angiotensinogen in the Proximal Tubules
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.3624-19
Abstract: Objective Urinary angiotensinogen (AGT) is a surrogate marker for intrarenal renin-angiotensin system (RAS) activity that plays an important role in the development of renal damage. Urinary AGT levels are determined by the filtration of plasma… read more here.
Keywords: urinary agt; production; angiotensinogen; urinary albumin ... See more keywords
Changes in Urinary Angiotensinogen Associated with Deterioration of Kidney Function in Patients with Type 2 Diabetes Mellitus
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DOI: 10.3346/jkms.2017.32.5.782
Abstract: Urinary angiotensinogen (AGT) is potentially a specific biomarker for the status of the intrarenal renin-angiotensin system (RAS) in patients with diabetes mellitus. We explored whether changes in urinary AGT excretion levels were associated with the… read more here.
Keywords: ras blockers; changes urinary; type diabetes; agt ... See more keywords
Immunosuppression by Mycophenolate Mofetil Mitigates Intrarenal Angiotensinogen Augmentation in Angiotensin II-Dependent Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147680
Abstract: Augmentation of intrarenal angiotensinogen (AGT) leads to further formation of intrarenal angiotensin II (Ang II) and the development of hypertensive kidney injury. Recent studies demonstrated that macrophages and the enhanced production of pro-inflammatory cytokines can… read more here.
Keywords: agt; immunosuppression mycophenolate; intrarenal angiotensinogen; hypertension ... See more keywords
Aspergillus Galactomannan Titer as a Diagnostic Marker of Invasive Pulmonary Aspergillosis in Lung Transplant Recipients: A Single-Center Retrospective Cohort Study
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DOI: 10.3390/jof9050527
Abstract: Invasive pulmonary aspergillosis (IPA) can occur in immunocompromised patients, and an early detection and intensive treatment are crucial. We sought to determine the potential of Aspergillus galactomannan antigen titer (AGT) in serum and bronchoalveolar lavage… read more here.
Keywords: agt; lung transplant; serum; balf ... See more keywords
Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
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DOI: 10.3390/molecules27248762
Abstract: The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein in the minor allele AGT-LM that contains the P11L… read more here.
Keywords: agt; aggregation; terminal segment; ntt agt ... See more keywords