Ruxolitinib treatment for SR-aGVHD in patients with EBV-HLH undergoing allo-HSCT
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DOI: 10.1007/s00277-019-03864-y
Abstract: Ruxolitinib is a promising option for treating steroid-refractory acute graft-versus-host disease (SR-aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we describe ruxolitinib treatment for SR-aGVHD in HSCT patients with Epstein-Barr virus-associated hemophagocytic… read more here.
Keywords: agvhd; ruxolitinib; patients ebv; treatment ... See more keywords
T Cell Costimulation Blockade with CTLA4-Ig (Abatacept) for Acute Gvhd Prevention in HLA Matched and Mismatched Unrelated Donor Transplantation: Results of the First Phase 2 Trial
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DOI: 10.1016/j.bbmt.2018.12.129
Abstract: We performed a Ph2 trial in adults and children to test abatacept for AGVHD prevention (‘ABA2’, Clinicaltrials # NCT01743131), based on our promising preclinical and pilot patient data. ABA2 had 2 cohorts: A) HLA-mismatched (‘7/8’,… read more here.
Keywords: aba; cni mtx; mtx atg; mtx ... See more keywords
Health Care Utilization and Financial Impact of Acute Graft-Versus-Host Disease (aGVHD) Among Children Undergoing Allogeneic Hematopoietic Cell Transplantation (alloHCT)
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DOI: 10.1016/j.bbmt.2018.12.240
Abstract: Introduction Steroids are the only effective treatment for acute GVHD and optimal salvage regimen for steroid refractory (SR) GVHD remains elusive. Impact of steroid sensitive (SS) and SR-AGVHD on healthcare utilization and cost is not… read more here.
Keywords: patients agvhd; agvhd among; impact; agvhd ... See more keywords
Recipient‐derived IL‐22 alleviates murine acute graft‐versus‐host disease in association with reduced activation of antigen presenting cells
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DOI: 10.1016/j.cyto.2018.08.010
Abstract: HighlightsKnock out of IL‐22 in recipients aggravates hepatic and intestinal aGVHD.IL‐22 mediates activation of dendritic cells.Recipient‐derived IL‐22 regulates polarization of Th1 cells and Tregs in aGVHD. Abstract Acute graft‐versus‐host disease (aGVHD) remains a major challenging… read more here.
Keywords: agvhd; recipient derived; versus host; recipient ... See more keywords
Adequate CD4+ T-cell reconstitution enhances survival probability after acute graft-versus-host-disease
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DOI: 10.1016/j.jcyt.2019.03.421
Abstract: Background & Aim Background Acute Graft-versus-Host-Disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic (stem) cell transplantation (HCT). Studies evaluating the relation between immune reconstitution (IR) and aGvHD are largely lacking.… read more here.
Keywords: acute graft; cd4; agvhd; adequate cd4 ... See more keywords
Healthcare utilization and financial impact of acute-graft-versus host disease among children undergoing allogeneic hematopoietic cell transplantation
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DOI: 10.1038/s41409-019-0688-9
Abstract: The impact of AGVHD on healthcare utilization and cost is not well described. In this retrospective single center cohort study of 240 pediatric patients, we analyzed cost, healthcare utilization and patient outcomes for the first… read more here.
Keywords: agvhd; impact; cost; among children ... See more keywords
Association of graft-versus-host-disease with neurologic complications: clinical paradigm and future directions
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DOI: 10.1038/s41409-021-01216-x
Abstract: Graft-versus-host disease (GVHD) is a well-known complication of hematopoietic cell transplantation (HCT) [1, 2]. GVHD can be classified into acute GVHD (aGVHD) and chronic GVHD (cGVHD), initially based at the day +100 mark, but corroborated… read more here.
Keywords: agvhd; cgvhd; disease; association ... See more keywords
Deciphering the effects of graft Tregs on chronic graft-versus-host disease: results from a prospective, multicenter study in patients with acute leukemia undergoing allogeneic peripheral blood stem cell transplantation
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DOI: 10.1038/s41409-022-01676-9
Abstract: TO THE EDITOR: Acute Graft versus Host Disease (aGvHD) after allogeneic hematopoietic stem cell transplant (allo-HSCT) may depend on known factors [1] such as: human leucocyte antigen (HLA) and/or sex mismatch, source of stem cell,… read more here.
Keywords: rate; agvhd; transplantation; disease ... See more keywords
REACH2: ruxolitinib for refractory aGvHD
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DOI: 10.1038/s41571-020-0385-z
Abstract: (median 5 months versus 1 month; HR 0.46, 95% CI 0.35–0.60) and overall survival (median 11.1 months versus 6.5 months; HR 0.83, 95% CI 0.60–1.15) also favoured ruxolitinib. With regard to toxicity, increased day-28 rates… read more here.
Keywords: refractory agvhd; reach2 ruxolitinib; agvhd; ruxolitinib refractory ... See more keywords
The incidence, risk factors, and outcomes of acute graft‐vs‐host disease in pediatric T‐cell‐replete haploidentical hematopoietic stem cell transplantation
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DOI: 10.1111/petr.13793
Abstract: The specific description, risk factors, and outcomes of aGVHD in pediatric haplo‐HSCT using TCR protocols without PT‐Cy have not been well described previously. We evaluated the incidence, risk factors, and outcomes of aGVHD in 350… read more here.
Keywords: incidence; agvhd; risk factors; cell ... See more keywords
β2-adrenergic receptor activation on donor cells ameliorates acute GvHD.
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DOI: 10.1172/jci.insight.137788
Abstract: Acute graft versus host disease (aGvHD) remains a major impediment to successful allogeneic hematopoietic cell transplantation (allo-HCT). To solve this problem, a greater knowledge of factors which regulate the differentiation of donor T cells toward… read more here.
Keywords: agvhd; donor cells; donor; activation ... See more keywords