From the Cover: Development and Application of a Dual Rat and Human AHR Activation Assay
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx188
Abstract: Significant prolonged aryl hydrocarbon receptor (AHR) activation, classically exhibited following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, can cause a variety of undesirable toxicological effects. Novel pharmaceutical chemistries also have the potential to cause activation of AHR and consequent… read more here.
Keywords: ahr activation; human ahr; activation; cover development ... See more keywords
Abstract 3710: Serum tryptophan metabolites mediate constitutive AHR activity in head and neck squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3710
Abstract: The aryl hydrocarbon receptor (AHR) is transcription factor, that is activated upon binding to various exogenous and endogenous ligands. AHR activation leads to induction of target gene expression, including the members of cytochrome P450 enzyme… read more here.
Keywords: tryp; tryp metabolites; cell; ahr activation ... See more keywords
Proper modulation of AHR signaling is necessary for establishing neural connectivity and oligodendrocyte precursor cell development in the embryonic zebrafish brain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1032302
Abstract: 2,3,7,8-tetrachlorodibenzo-[p]-dioxin (TCDD) is a persistent global pollutant that exhibits a high affinity for the aryl hydrocarbon receptor (AHR), a ligand activated transcription factor. Epidemiological studies have associated AHR agonist exposure with multiple human neuropathologies. Consistent… read more here.
Keywords: neural connectivity; modulation; development; brain ... See more keywords
Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082499
Abstract: Aryl hydrocarbon receptor (AhR) activation by environmental agents and microbial metabolites is potentially implicated in a series of skin diseases. Hence, it would be very important to identify natural compounds that could inhibit the AhR… read more here.
Keywords: human keratinocytes; aryl hydrocarbon; skin diseases; ahr activation ... See more keywords