Feedback Control of AHR Signaling Regulates Intestinal Immunity
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21080
Abstract: The aryl hydrocarbon receptor (AHR) recognizes xenobiotics as well as natural compounds such as tryptophan metabolites, dietary components and microbiota-derived factors, and it is important for maintenance of homeostasis at mucosal surfaces. AHR activation induces… read more here.
Keywords: control ahr; feedback control; ahr ligands;
Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2019.1635987
Abstract: Abstract The role of aryl hydrocarbon receptor (AhR) as a ligand-activated transcription factor in the field of cancer has gradually been unveiled. A strong body of evidence indicated that AhR is implicated in cell proliferation… read more here.
Keywords: hydrocarbon receptor; ahr; ahr ligands; aryl hydrocarbon ... See more keywords
TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx215
Abstract: FICZ and TCDD, two high-affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic… read more here.
Keywords: affinity ahr; high affinity; cell differentiation; ahr ligands ... See more keywords
Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.1101/2023.01.24.525336
Abstract: Dietary compounds can affect the development of inflammatory responses at distant sites. However, mechanisms involved remain incompletely understood. Here we addressed the influence on allergic responses of dietary agonists of Aryl Hydrocarbon Receptor (AhR). In… read more here.
Keywords: hydrocarbon receptor; dietary ahr; ahr ligands; allergic responses ... See more keywords
Invited Perspective: Environmental Chemical-Sensing AHR Remains an Enigmatic Key Player in Toxicology
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Health Perspectives"
DOI: 10.1289/ehp12535
Abstract: Over the last several years, the aryl hydrocarbon receptor (AHR) has gone from being characterized as not only a receptor that modulates cellular responses to myriad external environmental changes but also as one that regulates… read more here.
Keywords: toxicology; cell; ahr ligands; number ... See more keywords
AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.630938
Abstract: In agreement with other fungal infections, immunoprotection in pulmonary paracoccidioidomycosis (PCM) is mediated by Th1/Th17 cells whereas disease progression by prevalent Th2/Th9 immunity. Treg cells play a dual role, suppressing immunity but also controlling excessive… read more here.
Keywords: fungal infection; infection; ahr ligands; ch223191 ... See more keywords
The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.684727
Abstract: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates T cell function. The aim of this study was to investigate the effects of AhR ligands, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), and 6-Formylindolo[3,2-b]carbazole (FICZ), on gut-associated microbiota… read more here.
Keywords: response; ahr ligands; gut microbiota; dth response ... See more keywords
The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer
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DOI: 10.3390/cancers14225574
Abstract: Simple Summary The aryl hydrocarbon receptor (AhR) is expressed in breast cancer cells and tumors and in some studies, the AhR is a negative prognostic factor for patient survival. Structurally diverse AhR ligands have been… read more here.
Keywords: breast cancer; cancer; receptor; ahr ligands ... See more keywords
UVB Radiation and Selected Tryptophan-Derived AhR Ligands—Potential Biological Interactions in Melanoma Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22147500
Abstract: Excessive UV exposure is considered the major environmental factor in melanoma progression. Human skin is constantly exposed to selected tryptophan-derived aryl hydrocarbon receptor (AhR) ligands, including kynurenine (KYN) and kynurenic acid (KYNA), as they are… read more here.
Keywords: ahr ligands; tryptophan; melanoma cells; selected tryptophan ... See more keywords
Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14163253
Abstract: Background: Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) patients without specific treatment. Aryl hydrocarbon receptor (AhR) activation is associated with better outcomes in intestinal inflammation. Development of novel therapies targeting fibrogenic… read more here.
Keywords: human colonic; dietary ahr; ahr ligands; tgf stimulated ... See more keywords
Aryl Hydrocarbon Receptor (AhR)-Mediated Signaling in iPSC-Derived Human Motor Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070828
Abstract: Exposure to environmental pollutants and endogenous metabolites that induce aryl hydrocarbon receptor (AhR) expression has been suggested to affect cognitive development and, particularly in boys, also motor function. As current knowledge is based on epidemiological… read more here.
Keywords: motor neurons; human motor; ahr ligands; expression ... See more keywords