Sinomenine increases adenosine A2A receptor and inhibits NF‐κB to inhibit arthritis in adjuvant‐induced‐arthritis rats and fibroblast‐like synoviocytes through α7nAChR
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DOI: 10.1002/jlb.3ma0121-024rrrr
Abstract: Sinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti‐inflammatory… read more here.
Keywords: a2a receptor; adenosine a2a; sin; arthritis ... See more keywords
Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-Like Synoviocytes.
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DOI: 10.1080/21655979.2021.1999554
Abstract: Dehydroevodiamine (DHE) is an effective natural active substance extracted from Euodiae Fructus, which is a widely used herbal drug in traditional Chinese medicine. The focus of this study was to test the possibility of using… read more here.
Keywords: induced arthritis; human fibroblast; aia rats; adjuvant induced ... See more keywords
Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling
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DOI: 10.2147/dddt.s320599
Abstract: Background The Chinese herbal formula Qing-Luo-Yin (QLY) has been successfully used in rheumatoid arthritis treatment for decades. It exhibits notable immune and metabolism regulatory properties. Thereby, we investigated its effects on the interplay between (pre)-adipocytes… read more here.
Keywords: expression; arthritis; aia rats; monocytes macrophages ... See more keywords