AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4211-9
Abstract: Aims/hypothesisIn this study, we aimed to evaluate the therapeutic potential of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase, for ameliorating high-fat diet (HFD)-induced pathophysiology in mice. We also aimed to determine whether the… read more here.
Keywords: fat diet; aicar; tissue; pathophysiology ... See more keywords
Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Acta Diabetologica"
DOI: 10.1007/s00592-018-1130-2
Abstract: Aims5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. Loss and/or reduction of AMPK signaling plays an important role in the development of insulin resistance in type 2 diabetes.… read more here.
Keywords: urine levels; riboside aicar; aicar; type diabetes ... See more keywords
AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Science"
DOI: 10.1007/s11596-020-2266-1
Abstract: Although the advent of tyrosine kinase inhibitors (TKIs) has dramatically improved the survival of patients with chronic myeloid leukaemia (CML), acquired drug resistance and TKI-insensitive leukaemic stem cells (LSCs) remain major obstacles to a CML… read more here.
Keywords: k562 cells; aicar; aicar decitabine; sensitivity k562 ... See more keywords
AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02137
Abstract: Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. Though the gene regulatory mechanism for pluripotency has been investigated in recent years, it is still not completely… read more here.
Keywords: pluripotency; aicar; stem cells; gsk3 catenin ... See more keywords
Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac222
Abstract: Targeting AMPK is emerging as a promising strategy for treating myotonic dystrophy type 1 (DM1), the most prevalent form of adult-onset muscular dystrophy. We previously demonstrated that AICAR and exercise, two potent AMPK activators, improve… read more here.
Keywords: dystrophy type; sex; aicar; myotonic dystrophy ... See more keywords
AMPK activation by dietary AICAR affects the growth performance and glucose and lipid metabolism in juvenile grass carp
Sign Up to like & getrecommendations! Published in 2019 at "Aquaculture Nutrition"
DOI: 10.1111/anu.12951
Abstract: Fish are poor users of dietary carbohydrates and considered to be glucose intolerant, and activating AMP‐activated protein kinase (AMPK) by 5‐aminoimidazole‐4‐carboxamide ribonucleoside (AICAR) has been shown to stimulate glucose uptake and utilization in skeletal muscle… read more here.
Keywords: growth performance; dietary aicar; aicar; grass carp ... See more keywords
AICAR prevents fat gain following the cessation of voluntary physical activity
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Physiology"
DOI: 10.1113/ep086335
Abstract: The transition from physical activity to inactivity is associated with drastic increases in ‘catch-up’ fat that in turn foster the development of many obesity-associated maladies. We tested if 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) treatment would prevent gains… read more here.
Keywords: fat gain; aicar; activity aicar; cyclin mrna ... See more keywords
AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2021-0308
Abstract: Abstract Objectives AICAR, an adenosine analog, has been shown to exhibit vascular protective effects through activation of AMP-activated protein kinase (AMPK). However, it remains unclear as to whether adenosine kinase-mediated ZMP formation or adenosine receptor… read more here.
Keywords: amp activated; activation; muscle; kinase ... See more keywords
AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20071647
Abstract: Current clinical challenges of prostate cancer management are to restrict tumor growth and prohibit metastasis. AICAR (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. However, the activity… read more here.
Keywords: aicar; prostate cancer; cancer cells; cancer ... See more keywords
AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415719
Abstract: The aim of the study was to investigate the effect of AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on the consequences of metabolic syndrome and type 2 diabetes induced by the consumption of a high-fat… read more here.
Keywords: syndrome type; metabolic syndrome; fat; type diabetes ... See more keywords