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   Articles with "aicar" as a keyword



AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin

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recommendations! Published in 2017 at "Diabetologia"

DOI: 10.1007/s00125-017-4211-9

Abstract: Aims/hypothesisIn this study, we aimed to evaluate the therapeutic potential of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase, for ameliorating high-fat diet (HFD)-induced pathophysiology in mice. We also aimed to determine whether the… read more here.

Keywords: fat diet; aicar; tissue; pathophysiology ... See more keywords

Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes

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recommendations! Published in 2018 at "Acta Diabetologica"

DOI: 10.1007/s00592-018-1130-2

Abstract: Aims5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. Loss and/or reduction of AMPK signaling plays an important role in the development of insulin resistance in type 2 diabetes.… read more here.

Keywords: urine levels; riboside aicar; aicar; type diabetes ... See more keywords

AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity

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recommendations! Published in 2020 at "Current Medical Science"

DOI: 10.1007/s11596-020-2266-1

Abstract: Although the advent of tyrosine kinase inhibitors (TKIs) has dramatically improved the survival of patients with chronic myeloid leukaemia (CML), acquired drug resistance and TKI-insensitive leukaemic stem cells (LSCs) remain major obstacles to a CML… read more here.

Keywords: k562 cells; aicar; aicar decitabine; sensitivity k562 ... See more keywords

AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin

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recommendations! Published in 2020 at "ACS Omega"

DOI: 10.1021/acsomega.0c02137

Abstract: Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. Though the gene regulatory mechanism for pluripotency has been investigated in recent years, it is still not completely… read more here.

Keywords: pluripotency; aicar; stem cells; gsk3 catenin ... See more keywords

HOPE and AMPK activation reduce reperfusion injury and metabolic dysfunction in primate steatotic liver grafts

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-96265-3

Abstract: Living liver transplantation has become a significant and evolving aspect of organ transplantation, with a notable proportion of cases involving pediatric patients. Metabolic-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease. The… read more here.

Keywords: aicar; steatotic liver; liver grafts; reperfusion ... See more keywords

Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner.

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recommendations! Published in 2022 at "Human molecular genetics"

DOI: 10.1093/hmg/ddac222

Abstract: Targeting AMPK is emerging as a promising strategy for treating myotonic dystrophy type 1 (DM1), the most prevalent form of adult-onset muscular dystrophy. We previously demonstrated that AICAR and exercise, two potent AMPK activators, improve… read more here.

Keywords: dystrophy type; sex; aicar; myotonic dystrophy ... See more keywords
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AMPK activation by dietary AICAR affects the growth performance and glucose and lipid metabolism in juvenile grass carp

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recommendations! Published in 2019 at "Aquaculture Nutrition"

DOI: 10.1111/anu.12951

Abstract: Fish are poor users of dietary carbohydrates and considered to be glucose intolerant, and activating AMP‐activated protein kinase (AMPK) by 5‐aminoimidazole‐4‐carboxamide ribonucleoside (AICAR) has been shown to stimulate glucose uptake and utilization in skeletal muscle… read more here.

Keywords: growth performance; dietary aicar; aicar; grass carp ... See more keywords

AICAR prevents fat gain following the cessation of voluntary physical activity

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recommendations! Published in 2017 at "Experimental Physiology"

DOI: 10.1113/ep086335

Abstract: The transition from physical activity to inactivity is associated with drastic increases in ‘catch-up’ fat that in turn foster the development of many obesity-associated maladies. We tested if 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) treatment would prevent gains… read more here.

Keywords: fat gain; aicar; activity aicar; cyclin mrna ... See more keywords

5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) improves lipid utilization but not survival following prolonged hemorrhagic shock

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recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.731

Abstract: Hemorrhagic shock induces insulin resistance and cellular ATP depletion, the initial step for cell death and organ injury. AMPK is a fuel-sensing enzyme that maintains ATP production by facilitating glucose and fatty acid uptake and… read more here.

Keywords: aicar; physiology; peg; hemorrhagic shock ... See more keywords

AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle

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recommendations! Published in 2022 at "Journal of Basic and Clinical Physiology and Pharmacology"

DOI: 10.1515/jbcpp-2021-0308

Abstract: Abstract Objectives AICAR, an adenosine analog, has been shown to exhibit vascular protective effects through activation of AMP-activated protein kinase (AMPK). However, it remains unclear as to whether adenosine kinase-mediated ZMP formation or adenosine receptor… read more here.

Keywords: amp activated; activation; muscle; kinase ... See more keywords

AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway

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recommendations! Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20071647

Abstract: Current clinical challenges of prostate cancer management are to restrict tumor growth and prohibit metastasis. AICAR (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. However, the activity… read more here.

Keywords: aicar; prostate cancer; cancer cells; cancer ... See more keywords