APP Induces AICD-Mediated Autophagy-Dependent Axon Degeneration.
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DOI: 10.1111/acel.70301
Abstract: The amyloid precursor protein (APP) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). While the production of Amyloid beta (Aβ) has traditionally been considered the primary cause of AD, the role of… read more here.
Keywords: autophagy dependent; app; degeneration; axon degeneration ... See more keywords
The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abk3411
Abstract: Gain-of-function mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are common in familial forms of Parkinson’s disease (PD), which is characterized by progressive neurodegeneration that impairs motor and cognitive function. We previously demonstrated that… read more here.
Keywords: aicd; parkinson disease; lrrk2 expression; feed forward ... See more keywords