Computer‐aided design to enhance the stability of aldo‐keto reductase KdAKR
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300637
Abstract: The aldo‐keto reductase (AKR) KdAKR from Kluyvermyces dobzhanskii can reduce t‐butyl 6‐chloro‐(5S)‐hydroxy‐3‐oxohexanoate ((5S)‐CHOH) to t‐butyl 6‐chloro‐(3R,5S)‐dihydroxyhexanoate ((3R,5S)‐CDHH), which is the key chiral intermediate of rosuvastatin. Herein, a computer‐aided design that combined the use of PROSS… read more here.
Keywords: aided design; stability; aldo keto; computer aided ... See more keywords
Are their designs iterative or fixated? Investigating design patterns from student digital footprints in computer-aided design software
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Technology and Design Education"
DOI: 10.1007/s10798-017-9408-1
Abstract: This paper investigates iteration and fixation in design by mining digital footprints left by designers. High school students used computer-aided design software to create buildings in an urban area, with the goal of applying passive… read more here.
Keywords: design software; aided design; digital footprints; computer aided ... See more keywords
Development of a novel mandibular distraction osteogenesis simulator using Computer Aided Design and 3D printing.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2021.110616
Abstract: INTRODUCTION Micrognathia, a component of Robin Sequence, can cause glossoptosis, failure of palatal fusion, and critical obstruction of the airway. Mandibular distraction osteogenesis (MDO) is at times offered to anteriorly translate the mandible and tongue,… read more here.
Keywords: mandibular distraction; simulator; aided design; distraction osteogenesis ... See more keywords
Computer-aided design tool for typical flexible mechanisms synthesis by means of evolutionary algorithms
Sign Up to like & getrecommendations! Published in 2024 at "Robotica"
DOI: 10.1017/s0263574724000171
Abstract: Abstract Accurate prediction for mechanisms’ dynamic responses has always been a challenging task for designers. For modeling easiness purposes, mechanisms’ synthesis and optimization have been mostly limited to rigid systems, making consequently the designer unable… read more here.
Keywords: aided design; synthesis; mechanism; design tool ... See more keywords
Computer-Aided Design of 3D Non-Enzymatic Catalytic Cascade Systems for In Situ Multiplexed mRNA Imaging in Single-Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c06589
Abstract: mRNA, a critical biomarker for various diseases and a promising target for cancer therapy, is central to biological and medical research. However, the development of multiplexed approaches for in situ monitoring of mRNA in live… read more here.
Keywords: nucleic acid; mrna; aided design; computer aided ... See more keywords
Enhanced Sampling Aided Design of Molecular Photoswitches.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04419
Abstract: Advances in the evolving field of atomistic simulations promise important insights for the design and fundamental understanding of novel molecular photoswitches. Here, we use state-of-the-art enhanced simulation techniques to unravel the complex, multistep chemistry of… read more here.
Keywords: sampling aided; design molecular; enhanced sampling; aided design ... See more keywords
Computer-aided design of metal chalcohalide semiconductors: from chemical composition to crystal structure† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03961a
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c7sc03961a
Abstract: The standard paradigm in computational materials science is INPUT: Structure; OUTPUT: Properties, which has yielded many successes but is ill-suited for exploring large areas of chemical and configurational hyperspace. read more here.
Keywords: metal chalcohalide; chalcohalide semiconductors; aided design; structure ... See more keywords
Surface Properties and Wear Resistance of Injectable and Computer-Aided Design/Computer Aided Manufacturing-Milled Resin Composite Thin Occlusal Veneers.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of dentistry"
DOI: 10.1055/s-0042-1750769
Abstract: OBJECTIVES This study was conducted to investigate the microhardness, surface roughness (Ra), and wear behavior of thin occlusal veneers (TOV) fabricated from different injectable composite materials and compare them to a Computer-Aided Design (CAD)/Computer-Aided Manufacturing… read more here.
Keywords: thin occlusal; occlusal veneers; aided design; aided manufacturing ... See more keywords
Computer aided design of stable and efficient OLEDs
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Physics"
DOI: 10.1063/5.0022870
Abstract: Organic light emitting diodes (OLEDs) offer a unique alternative to traditional display technologies. Tailored device architecture can offer properties such as flexibility and transparency, presenting unparalleled application possibilities. Commercial advancement of OLEDs is highly anticipated,… read more here.
Keywords: stable efficient; design stable; aided design; computer aided ... See more keywords
3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2024.2409913
Abstract: ABSTRACT Introduction The challenge in tissue engineering lies in replicating the intricate structure of the native extracellular matrix. Recent advancements in AM, notably 3D printing, offer unprecedented capabilities to tailor scaffolds precisely, controlling properties like… read more here.
Keywords: aided design; engineering; tissue engineering; computer aided ... See more keywords
Towards computer aided design of cellular structure.
Sign Up to like & getrecommendations! Published in 2020 at "Physical biology"
DOI: 10.1088/1478-3975/ab6d43
Abstract: Cells are complex machines with tremendous potential for applications in medicine and biotechnology. Although much effort has been devoted to engineering the metabolic, genetic, and signaling pathways of cells, methods for systematically engineering the physical… read more here.
Keywords: cellular structure; aided design; computer aided; structure ... See more keywords