Microglial AIM2 alleviates antiviral‐related neuro‐inflammation in mouse models of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24260
Abstract: Inflammasome involvement in Parkinson's disease (PD) has been intensively investigated. Absent in melanoma 2 (AIM2) is an essential inflammasome protein known to contribute to the development of several neurological diseases. However, a specific role for… read more here.
Keywords: aim2; neuro inflammation; mouse; antiviral related ... See more keywords
AIM2 promotes non‐small‐cell lung cancer cell growth through inflammasome‐dependent pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28617
Abstract: The human absent in melanoma 2 (AIM2) is considered as a DNA recognizer. AIM2 has been described as a tumor suppressor gene in the early years. But recent studies suggested that it functions as an… read more here.
Keywords: aim2; lung cancer; cell lung; non small ... See more keywords
CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.022
Abstract: BACKGROUND Recent studies have implicated inflammatory processes in the pathophysiology of posttraumatic stress disorder (PTSD). C-reactive protein (CRP) is a widely-used measure of peripheral inflammation, but little is known about the genetic and epigenetic factors… read more here.
Keywords: methylation; aim2; reactive protein; crp ... See more keywords
Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren's syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102381
Abstract: Primary Sjögren's syndrome (SS) is characterized by chronic periductal inflammatory infiltrates in the salivary glands. Several previous studies have indicated that the ductal epithelia of SS patients play a pro-inflammatory role and manifest an intrinsically… read more here.
Keywords: sgec lines; aim2; dna; cytoplasmic dna ... See more keywords
Aim2 suppresses cigarette smoke‐induced neutrophil recruitment, neutrophil caspase‐1 activation and anti‐Ly6G‐mediated neutrophil depletion
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12537
Abstract: Increased inflammasome responses are strongly implicated in inflammatory diseases; however, their specific roles are incompletely understood. Therefore, we sought to examine the roles of nucleotide‐binding oligomerization domain–like receptor (NLR) family, pyrin domain–containing 3 (NLRP3) and… read more here.
Keywords: cigarette smoke; aim2; smoke induced; anti ly6g ... See more keywords
The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12641
Abstract: Helicobacter pylori (H. pylori) infection can trigger chronic gastric inflammation perpetuated by overactivation of the innate immune system, leading to a cascade of precancerous lesions culminating in gastric cancer. However, key regulators of innate immunity that… read more here.
Keywords: aim2; helicobacter induced; gastric pathology; cytosolic dna ... See more keywords
Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17573
Abstract: Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal… read more here.
Keywords: aim2; tumor cell; expression; cell ... See more keywords
AIM2 Stimulation Impairs Reendothelialization and Promotes the Development of Atherosclerosis in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2020.582482
Abstract: Background: Atherosclerosis has been shown to result from chronic inflammation caused by constitutive activation of the pattern recognition receptors (PRR), which are principle effectors of the innate immune system. PRR are present in the endosome… read more here.
Keywords: reendothelialization; aim2; stimulation impairs; mice ... See more keywords
AIM2 and Psoriasis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1085448
Abstract: Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic complications, which seriously affect the quality of life and physical and mental health of patients. The pathogenesis of psoriasis is related to the… read more here.
Keywords: psoriasis; aim2; aim2 psoriasis;
Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042230
Abstract: Absent in melanoma 2 (AIM2) is a cytosolic dsDNA sensor that has been broadly studied for its role in inflammasome assembly. However, little is known about the function of AIM2 in adaptive immune cells. The… read more here.
Keywords: melanoma aim2; cell; aim2; cd4 ... See more keywords
Autoinflammation in Syndromic Hidradenitis Suppurativa: The Role of AIM2
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11010162
Abstract: Background: AIM2 is a key cytoplasmatic pathogen-sensor that detects foreign DNA from viruses and bacteria; it can also recognize damaged or anomalous presence of DNA, promoting inflammasome assembly and activation with the secretion of IL-1β,… read more here.
Keywords: aim2; syndromic hidradenitis; role; hidradenitis suppurativa ... See more keywords