AIM2 Inflammasome Assembly and Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_7
Abstract: AIM2 (absent in melanoma 2) is a cytoplasmic sensor of double-stranded DNA from pathogens or damaged cellular organelles. It recruits ASC (apoptosis-associated specklike protein containing a CARD) and caspase-1 to form the AIM2 inflammasome, activate… read more here.
Keywords: caspase; aim2 inflammasome; assembly signaling; assembly ... See more keywords
Short-lived AIM2 Inflammasome Activation Relates to Chronic MCMV Infection in BALB/c Mice
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2121-4
Abstract: Absent in melanoma 2 (AIM2) inflammasome is a crucial link bridging the innate host defense and the subsequent adaptive immunity when activated by exogenous double stranded DNA (dsDNA). Through establishing models of disseminated murine cytomegalovirus… read more here.
Keywords: day; mcmv; aim2 inflammasome; balb mice ... See more keywords
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.02.004
Abstract: Loss of lymphocytes, particularly T cell apoptosis, is a central pathological event after severe tissue injury that is associated with increased susceptibility for life-threatening infections. The precise immunological mechanisms leading to T cell death after acute injury… read more here.
Keywords: aim2 inflammasome; cell; cell death; post injury ... See more keywords
Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.10.028
Abstract: Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to… read more here.
Keywords: caspase; death; aim2 inflammasome; cleavage ... See more keywords
SOCS3 protects against neonatal necrotizing enterocolitis via suppressing NLRP3 and AIM2 inflammasome activation and p65 nuclear translocation.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.03.019
Abstract: BACKGROUND Necrotizing enterocolitis (NEC) is an acquired disorder of mucosal damage characterized by the diffuse or local necrosis of the intestine. The suppressor of cytokine signaling 3 (SOCS3) has been demonstrated to possess anti-inflammatory action… read more here.
Keywords: aim2 inflammasome; socs3; p65 nuclear; nlrp3 aim2 ... See more keywords
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2016.35
Abstract: Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the… read more here.
Keywords: aim2 inflammasome; stat3 pathway; colorectal cancer; stat3 ... See more keywords
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201494119
Abstract: Significance Chronic lung inflammation triggered by dysregulated activation of innate immunity is implicated in pulmonary emphysema. However, key innate immune molecular regulators that trigger emphysema remain ill-defined. We reveal innate immune multiprotein inflammasome complexes comprising… read more here.
Keywords: cross talk; epithelial apoptosis; emphysema; aim2 inflammasome ... See more keywords
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00003-23
Abstract: PRV can infect several mammals, including pigs, other livestock, rodents, and wild animals, causing huge economic losses. As an emerging and reemerging infectious disease, the emergence of PRV virulent isolates and increasing human PRV infection… read more here.
Keywords: prv infection; inflammatory responses; infection; aim2 inflammasome ... See more keywords
Role of caspase-1 and AIM2 inflammasome in ischemia/reperfusion injury of myocardium
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733390
Abstract: Acute myocardial infarction induces a sterile inflammatory response, leading to cardiomyocyte damage and adverse cardiac remodeling. The contribution of inflammasomes has been involved to the cardiac remodeling, however, little is known about its potential role… read more here.
Keywords: ischemia; physiology; aim2 inflammasome; mice ... See more keywords
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.155563
Abstract: Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory responses… read more here.
Keywords: eae; inflammasome activated; inflammasome activation; aim2 inflammasome ... See more keywords
Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4145409
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Psoralea corylifolia (P. corylifolia Linn.) is a traditional Chinese medicinal plant that exhibits significant aphrodisiac, diuretic, and anti-rheumatic effects. However, it has been reported to cause hepatic injury, but the precise mechanisms remain… read more here.
Keywords: bak; bakuchiol; cause; aim2 inflammasome ... See more keywords