Peripheral nerves are involved in hypomyelinating leukodystrophy-3 caused by a homozygous AIMP1 variant
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DOI: 10.1016/j.braindev.2020.12.008
Abstract: INTRODUCTION Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) is a non-catalytic component of the multi-tRNA synthetase complex that catalyzes the ligation of amino acids to their correct tRNAs. Bi-allelic truncating variants in the AIMP1 gene have… read more here.
Keywords: hypomyelinating leukodystrophy; aimp1; peripheral nerves; aimp1 variant ... See more keywords
Suppression of AIMP1 protects cognition in Alzheimer’s disease model mice 3xTg-AD
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DOI: 10.1097/wnr.0000000000000710
Abstract: Neuroinflammation has been raised as a candidate of unifying pathogenesis and a target of a disease-modifying strategy for Alzheimer’s disease (AD). Aminoacyl-tRNA synthetase complex (ARS)-interacting multifunctional protein 1 (AIMP1) is a cytokine that is known… read more here.
Keywords: aimp1; alzheimer disease; anti aimp1; disease ... See more keywords