Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.
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DOI: 10.1016/j.devcel.2020.06.020
Abstract: Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solely by epigenetic deregulation. Michealraj et al. (2020) demonstrate that hypoxia reprograms PFA metabolism and, subsequently, the epigenome toward H3K27… read more here.
Keywords: air hypoxia; lethal pediatric; ependymoma; deregulation ... See more keywords