Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.05.003
Abstract: The human autoimmune disease-associated HLA alleles HLA-DR2b (DRB1*1501) and HLA-DR4 (DRB1*0401) are strongly linked to increased susceptibility for multiple sclerosis (MS) and rheumatoid arthritis (RA), respectively. The underlying mechanisms are not fully understood, but these… read more here.
Keywords: autoimmune; aire; hla dr2b; pathology ... See more keywords
Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110384
Abstract: Impaired production of thymic regulatory T cells (Tregs) is implicated in the development of Aire-dependent autoimmunity. Because Tregs require agonistic T cell receptor stimuli by self-antigens to develop, reduced expression of self-antigens from medullary thymic epithelial cells… read more here.
Keywords: autoimmunity; self antigens; ctla expression; aire ... See more keywords
Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Immunobiology"
DOI: 10.1016/j.imbio.2021.152147
Abstract: Autoimmune regulator (Aire) is a transcription factor that plays a pivotal role in the maintenance of immune tolerance. However, little is known about its roles in peripheral immune tolerance. Aire is predominantly expressed in dendritic… read more here.
Keywords: dc2 cells; cell differentiation; aire; tfh cell ... See more keywords
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.09.006
Abstract: Autoimmunity is prevented by the function of the autoimmune regulator [AIRE (Aire in mice)], which promotes the expression of a wide variety of tissue-restricted antigens (TRAs) from medullary thymic epithelial cells (mTECs) and from a… read more here.
Keywords: aire; autoimmune regulator; expression; autoimmunity ... See more keywords
Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.10.010
Abstract: A genetic variant in the SAND domain of autoimmune regulator (AIRE), R247C, was identified in a patient with type I diabetes mellitus (T1DM) and his mother with rheumatoid arthritis. In vitro, the variant dominantly inhibited AIRE;… read more here.
Keywords: sand domain; variant; aire; domain autoimmune ... See more keywords
Mechanism for controlled assembly of transcriptional condensates by Aire
Sign Up to like & getrecommendations! Published in 2024 at "Nature Immunology"
DOI: 10.1038/s41590-024-01922-w
Abstract: Transcriptional condensates play a crucial role in gene expression and regulation1–4, yet the mechanisms governing their assembly at the correct location and time remain poorly understood2,5–7. We here report a multi-layered mechanism for condensate assembly… read more here.
Keywords: mechanism controlled; transcriptional condensates; controlled assembly; aire ... See more keywords
Decreased expression of circulating Aire and increased Tfh/Tfr cells in myasthenia gravis patients
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180096
Abstract: Myasthenia gravis (MG) is a rare prototypical autoimmune disorder caused by antibodies (Ab) against postsynaptic membrane proteins. Most reports have investigated the role of autoimmune regulator gene (Aire) in thymic tissue in machianism of MG… read more here.
Keywords: aire; circulating aire; tfh tfr; expression ... See more keywords
Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2311487121
Abstract: Significance To model human autoimmune disease, which typically exhibits multigenic inheritance, we created mice with mutations in Aire and Lyn, which respectively alter thymic tolerance of T cells and peripheral activation of T cells. Fifty… read more here.
Keywords: tolerance; aire; model; tcr transgenic ... See more keywords
Autoimmune regulator (AIRE): Takes a hypoxia‐inducing factor 1A (HIF1A) route to regulate FOXP3 expression in PCOS
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13637
Abstract: Autoimmune polyendocrinopathy‐candidiasis‐ ectodermal dystrophy (APECED) pathology due to autoimmune regulator (AIRE) gene mutations leads to loss of central tolerance triggering immune attack, a factor causing infertility. One of the targets of autoimmune attack is ovary… read more here.
Keywords: factor; aire; regulator aire; autoimmune regulator ... See more keywords
Development of organ‐specific autoimmunity by dysregulated Aire expression
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12546
Abstract: Deficiency for AIRE/Aire in both humans and mice results in the development of organ‐specific autoimmune disease. We tested whether augmented and/or dysregulated AIRE/Aire expression might be also prone to the breakdown of self‐tolerance. To define… read more here.
Keywords: organ specific; autoimmunity; aire expression; expression ... See more keywords
The Autoimmune Regulator (Aire) transactivates HLA‐G gene expression in thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13099
Abstract: The Autoimmune Regulator (Aire) protein coordinates the negative selection of developing thymocytes by inducing the expression of hundreds of tissue‐specific antigens within the thymic medulla, which is also a primary site of the expression of… read more here.
Keywords: aire; regulator aire; autoimmune regulator; hla ... See more keywords