rAAV-MEDIATED EDITING OF THE G551D CFTR MUTATION IN FERRET AIRWAY BASAL CELLS.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.036
Abstract: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a chronic disease that affects multiple organs including the lung. We developed a CF ferret model of a scarless G551→D substitution… read more here.
Keywords: basal cells; cftr; gene editing; airway basal ... See more keywords
Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0299oc
Abstract: Histological and lineage immunofluorescence examination herein revealed that healthy conducting airways of humans and animals harbor sporadic poorly differentiated epithelial patches mostly in the dorsal non-cartilage regions that remarkably manifest squamous differentiation. In vitro analysis… read more here.
Keywords: basal cells; airway basal; reversible squamous; squamous differentiation ... See more keywords
Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.162041
Abstract: Keratin expression dynamically changes in airway basal cells (BCs) after acute and chronic injury, yet the functional consequences of these changes on BC behavior remain unknown. In bronchiolitis obliterans (BO) after lung transplantation, BC clonogenicity… read more here.
Keywords: basal cells; krt15; clonogenicity; airway basal ... See more keywords
Transcriptional Profiling reveals Reprogramming of Airway Basal Cells in IPF
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DOI: 10.1183/1393003.congress-2017.oa4441
Abstract: Introduction: Idiopathic pulmonary fibrosis is characterized by a vast remodeling of the alveolar compartment. Recent data indicate a role for airway basal cells in IPF. Methods: Bronchial epithelial cells of 30 patients with IPF and… read more here.
Keywords: cells ipf; airway basal; basal cells; reprogramming airway ... See more keywords