Mechanism of airway closure in acute respiratory distress syndrome: a possible role of surfactant depletion
Sign Up to like & getrecommendations! Published in 2018 at "Intensive Care Medicine"
DOI: 10.1007/s00134-018-5501-5
Abstract: Dear Editor, We recently reported the presence of airway closure in patients with acute respiratory distress syndrome (ARDS), evidenced by a low-flow inflation pressure–volume (P–V) curve [1]. We noticed that the initial slope of the… read more here.
Keywords: aop; surfactant depletion; airway closure; respiratory ... See more keywords
The effect of viscoelasticity in an airway closure model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fluid Mechanics"
DOI: 10.1017/jfm.2020.1162
Abstract: Abstract The closure of a human lung airway is modelled as a pipe coated internally with a liquid that takes into account the viscoelastic properties of mucus. For a thick-enough coating, the Plateau–Rayleigh instability blocks… read more here.
Keywords: effect viscoelasticity; model; viscoelasticity airway; airway closure ... See more keywords
Bronchial hyperresponsiveness and obesity in middle age: insights from an Australian cohort
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.02181-2016
Abstract: The association between obesity and bronchial hyperresponsiveness (BHR) is incompletely characterised. Using the 2006 follow-up of the Tasmanian Longitudinal Health Study, we measured the association between obesity and BHR and whether it was mediated by… read more here.
Keywords: association; obesity; airway closure; bronchial hyperresponsiveness ... See more keywords
Erroneous calibration of esophageal pressure in case of airway closure
Sign Up to like & getrecommendations! Published in 2025 at "Critical Care"
DOI: 10.1186/s13054-025-05416-5
Abstract: Airway closure results in a lack of communication between proximal and distal airways unless the airway pressure (Paw) overcomes the airway opening pressure (AOP). This has been described in patients undergoing mechanical ventilation with acute… read more here.
Keywords: pressure; calibration esophageal; esophageal pressure; airway closure ... See more keywords
Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Intensive Care"
DOI: 10.1186/s13613-024-01378-z
Abstract: Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical ventilation may depend on airway patency. We hypothesized that airway closure and lung collapse, countered by positive end-expiratory pressure (PEEP), influence iNO efficacy. This… read more here.
Keywords: ino; hemodynamics; effect; lung ... See more keywords
Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0208337
Abstract: Background Asthma exacerbations cause lung hyperinflation, elevation in load to inspiratory muscles, and decreased breathing capacity that, in severe cases, may lead to inspiratory muscle fatigue and respiratory failure. Hyperinflation has been attributed to a… read more here.
Keywords: lung volume; volume; elevation; airway closure ... See more keywords
Airway Closure and Expiratory Flow Limitation in Acute Respiratory Distress Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.815601
Abstract: Acute respiratory distress syndrome (ARDS) is mostly characterized by the loss of aerated lung volume associated with an increase in lung tissue and intense and complex lung inflammation. ARDS has long been associated with the… read more here.
Keywords: expiratory; airway closure; expiratory flow; lung ... See more keywords